| HGNC Family | Non-coding RNAs |
| Name | microRNA 604 |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have identified that MIR604 plays a role in modulating host responses during hepatitis B virus (HBV) infection. In one study, a polymorphism (rs2368392) in the precursor region of MIR604 was shown to influence disease outcomes in chronic HBV patients: individuals carrying the T allele had a higher risk of persistent HBV infection yet a lower risk of progressing to hepatocellular carcinoma, suggesting that this variant may function as a risk allele for viral chronicity while conferring protection against malignant transformation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies have focused on the role of MIR604 in reproductive outcomes. Investigations of MIR604 A>G polymorphisms, including variants within the seed sequence that affect binding to target genes such as methylenetetrahydrofolate reductase (MTHFR) and gonadotropin-releasing hormone receptor (GnRHR), have demonstrated significant associations with idiopathic recurrent pregnancy loss. In one study, the protective genotype (AG or AG+GG) was less frequent in patients with recurrent pregnancy loss compared to wild‐type counterparts, while another study in a Turkish cohort corroborated the association between the MIR604 polymorphism and decreased risk of recurrent miscarriage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jae Youn Cheong, Hyoung Doo Shin, Sung Won Cho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of polymorphism in microRNA 604 with susceptibility to persistent hepatitis B virus infection and development of hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Korean Med Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3346/jkms.2014.29.11.1523"}], "href": "https://doi.org/10.3346/jkms.2014.29.11.1523"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25408584"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25408584"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sung-Hwan Cho, Ji-Hyang Kim, Hui-Jeong An, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic Polymorphisms in "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "miR-604"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "A>G, "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "miR-938"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "G>A, "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "miR-1302-3"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "C>T and the Risk of Idiopathic Recurrent Pregnancy Loss."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22116127"}], "href": "https://doi.org/10.3390/ijms22116127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34200157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34200157"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Esra Tekcan, Ulas Coban, Mesut Onal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR604A>G gene polymorphism is associated with recurrent pregnancy loss in Turkish women."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Rev Assoc Med Bras (1992) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1590/1806-9282.20230454"}], "href": "https://doi.org/10.1590/1806-9282.20230454"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37729371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37729371"}]}]}]}
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| Synonyms | MIRN604, HSA-MIR-604 |
| NCBI Gene ID | 693189 |
| API | |
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| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MIR604 has 240 functional associations with biological entities spanning 5 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 17 datasets.
Click the + buttons to view associations for MIR604 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR604 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR604 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of MIR604 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR604 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR604 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR604 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of MIR604 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GAD Gene-Disease Associations | diseases associated with MIR604 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing MIR604 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of MIR604 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of MIR604 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with MIR604 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of MIR604 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR604 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of MIR604 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of MIR604 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR604 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
