{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR606 functions as a potent tumor suppressor in triple‐negative breast cancer (TNBC). In vitro, transfection with miR‑606 mimics significantly inhibited TNBC cell proliferation, migration, and invasion, reduced tumor sphere‐forming capacity, and induced apoptosis. In addition, in vivo studies using xenograft and tail vein metastasis mouse models demonstrated that forced expression of miR‑606 led to suppressed tumor growth and a decrease in lung metastatic nodules."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "MIR606 further demonstrates its clinical relevance by exhibiting an inverse correlation with the expression of STC1, a relationship that impacts patient overall survival in TNBC. These findings highlight the therapeutic potential of miR‑606 in countering tumor progression and metastasis, supporting its application in the development of anticancer miRNA‐based treatments."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sujin Choi, Hyun-Ju An, Hyun Jeong Yeo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑606 inhibits the growth and metastasis of triple‑negative breast cancer by targeting Stanniocalcin 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2023.8661"}], "href": "https://doi.org/10.3892/or.2023.8661"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37975233"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37975233"}]}]}]}