{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn a study of chronic brucellosis, researchers profiled more than 2000 miRNAs in peripheral blood mononuclear cells from patients with acute and chronic infection as well as from healthy controls. Notably, four miRNAs were uniquely dysregulated in chronic cases, among which MIR6069 was significantly downregulated compared to its expression in both acute infections and healthy individuals."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nIn-depth pathway analyses indicated that the predicted targets of MIR6069 are involved in key cellular processes—including endocytosis, regulation of the actin cytoskeleton, MAPK signaling, and cytokine–cytokine receptor interactions with an emphasis on chemokine signaling. This suggests that the reduced expression of MIR6069 in chronic brucellosis may contribute to alterations in immune cell function and pathogen processing that underlie the progression from an acute to a chronic state."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nCollectively, the results of this study support a potential role for MIR6069 not only as a useful biomarker for identifying chronic brucellosis but also as a functional player in modulating host cellular pathways critical to disease persistence. Further validation of MIR6069’s targets and mechanisms of action is warranted to fully elucidate its contribution to the immunopathogenesis of chronic infections."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ferah Budak, Salih Haldun Bal, Gulcin Tezcan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered Expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the Formation of Chronic Brucellosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2016/4591468"}], "href": "https://doi.org/10.1155/2016/4591468"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27722176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27722176"}]}]}]}