{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies implicate miR-607 as a pivotal regulatory microRNA whose activity is modulated by competing endogenous RNA networks in various cancers. In chronic lymphocytic leukemia, circ-CBFB acts as a molecular sponge for miR-607, thereby relieving its inhibitory effect on FZD3 expression. The subsequent activation of the Wnt/β‑catenin signaling pathway promotes proliferation and survival of malignant cells, underscoring the contribution of miR-607 sequestration to disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn pancreatic cancer, the long noncoding RNA LINC01559 similarly functions as a competing endogenous RNA by binding miR-607. This sponging effect not only diminishes miR-607’s regulation of its targets but also facilitates the interaction of LINC01559 with YAP protein, enhancing its transcriptional activity and thereby driving tumor proliferation and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In non‐small cell lung carcinoma, hsa_circ_0072309 exerts oncogenic influence via a comparable mechanism; by interacting with miR-607, it upregulates the expression of FTO, a key m6A demethylase, which further promotes tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, emerging clinical investigations have highlighted the diagnostic and prognostic significance of miR-607 in malignancies beyond these contexts. In pancreatic ductal adenocarcinoma and hepatocellular carcinoma, aberrant expression levels of miR-607 have been associated with enhanced cell proliferation and migration, suggesting that dysregulation of this microRNA may serve as an important biomarker and therapeutic target in these cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Liang Xia, Linlin Wu, Jing Bao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circ-CBFB promotes proliferation and inhibits apoptosis in chronic lymphocytic leukemia through regulating miR-607/FZD3/Wnt/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.06.045"}], "href": "https://doi.org/10.1016/j.bbrc.2018.06.045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29902450"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29902450"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Changjie Lou, Juan Zhao, Yuanlong Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01559 accelerates pancreatic cancer cell proliferation and migration through YAP-mediated pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29288"}], "href": "https://doi.org/10.1002/jcp.29288"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31608998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31608998"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wei-Lie Mo, Li-Jian Deng, Yun Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA hsa_circ_0072309 promotes tumorigenesis and invasion by regulating the miR-607/FTO axis in non-small cell lung carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202856"}], "href": "https://doi.org/10.18632/aging.202856"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33879631"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33879631"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Dawei Jiang, Xiangfei Yuan, Jianqi Ni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Low Serum miR-607 Level as a Potential Diagnostic and Prognostic Biomarker in Patients of Pancreatic Ductal Adenocarcinoma: A Preliminary Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Can J Gastroenterol Hepatol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/8882129"}], "href": "https://doi.org/10.1155/2021/8882129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34222137"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34222137"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "C Li, S Chen, Y Jiang "}, {"type": "b", "children": [{"type": "t", "text": "[Overexpression of miR-607 inhibits hepatocellular carcinoma cell growth and metastasis by down-regulating TRPC5]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nan Fang Yi Ke Da Xue Xue Bao (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12122/j.issn.1673-4254.2022.11.01"}], "href": "https://doi.org/10.12122/j.issn.1673-4254.2022.11.01"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36504050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36504050"}]}]}]}