{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR-6077 plays a critical role in augmenting the antitumor effects of anlotinib, a novel molecular targeted agent for non‐small cell lung cancer (NSCLC), by suppressing the expression of GLUT1 (glucose transporter 1). Bioinformatic analysis suggested that miR-6077 specifically binds to the 3′-untranslated region of the GLUT1 mRNA, thereby reducing its expression. This downregulation leads to diminished glucose uptake, lactate production, and ATP generation in lung adenocarcinoma cells, highlighting a metabolic reprogramming that may render the cancer cells more vulnerable to anlotinib therapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nExperimental validation in A549 cells and several patient-derived lung adenocarcinoma cell lines confirmed that overexpression of miR-6077 via lentiviral delivery significantly enhances the sensitivity of these cells to anlotinib. This was evidenced by inhibited cell proliferation in vitro and a pronounced antitumor effect in vivo using a subcutaneous tumor model. Together, these findings suggest that miR-6077 not only modulates tumor metabolism but also potentiates the efficacy of anlotinib, providing a promising strategy to improve therapeutic outcomes in advanced NSCLC patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "De-Bin Ma, Meng-Meng Qin, Liang Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-6077 enhances the sensitivity of patients-derived lung adenocarcinoma cells to anlotinib by repressing the activation of glucose transporter 1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2019.109391"}], "href": "https://doi.org/10.1016/j.cellsig.2019.109391"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31421224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31421224"}]}]}]}