{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn human endothelial cells, hsa‐miR-6086 is markedly induced by TNFα stimulation, where it plays a crucial role in mediating inflammatory responses. Specifically, miR-6086 downregulates the expression of CDH5—a key adhesion molecule essential for endothelial cell survival—thereby contributing to TNFα-induced growth inhibition and apoptosis. This modulation of CDH5 expression suggests that miR-6086 helps drive endothelial dysfunction under inflammatory conditions, pointing to its potential as a therapeutic target in cardiovascular disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn ovarian cancer, miR-6086 appears to function as a suppressor of tumor angiogenesis. It is found at very low levels in ovarian cancer cell lines and tissues, and experimental upregulation of miR-6086 directly targets transcription factor OC2 and the protein EGFL6. By interfering with the OC2/VEGFA/EGFL6 axis, miR-6086 indirectly reduces the levels of the potent angiogenic factor VEGFA. Consequently, enhanced miR-6086 expression leads to significant inhibition of tumor cell proliferation, migration, invasion, and angiogenesis via attenuation of the AKT/MAPK signaling pathways—highlighting its promise as a potential therapeutic tool in the management of ovarian cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xueli Cai, Xi Zhou, Fangyi Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of hsa-miR-6086 protects human umbilical vein endothelial cells against TNFα-induced proliferation inhibition and apoptosis via CDH5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2018.03.091"}], "href": "https://doi.org/10.1016/j.gene.2018.03.091"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29605606"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29605606"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Binhua Wu, Ligang Zhang, Yunfei Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-6086 inhibits ovarian cancer angiogenesis by downregulating the OC2/VEGFA/EGFL6 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-2501-5"}], "href": "https://doi.org/10.1038/s41419-020-2501-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32393810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32393810"}]}]}]}