MIR609 Gene

HGNC Family Non-coding RNAs
Name microRNA 609
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nCurrent research on MIR609 reveals distinct investigative avenues. Although one study focused on caspase-11-mediated innate immune responses to cytoplasmic lipopolysaccharide (LPS), no direct involvement of MIR609 was reported in that context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, another study specifically assessed serum microRNA-609 levels, evaluating its potential as a clinical prognostic biomarker in patients with thalassemia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n \nIn the thalassemia study, MIR609 was examined for its expression in serum, with findings suggesting that variations in its levels could correlate with disease prognosis. Although the mechanistic role of MIR609 was not dissected in detail, its evaluation points to a potential utility as a non-invasive biomarker for monitoring disease progression and predicting clinical outcomes.\n\nOverall, while the first abstract does not provide functional data regarding MIR609, the serum-level investigation in the second abstract highlights its emerging prognostic significance in thalassemia, underscoring the importance of further research into its biological functions and regulatory networks.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jon A Hagar, Daniel A Powell, Youssef Aachoui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1240988"}], "href": "https://doi.org/10.1126/science.1240988"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24031018"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24031018"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ming-Quan Wang, Ling-Li Cheng, Jing-Jing Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Serum Level of MiR-609 and Its Clinical Prognostic Value in Patients with Thalassemia]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhongguo Shi Yan Xue Ye Xue Za Zhi (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.19746/j.cnki.issn.1009-2137.2019.06.036"}], "href": "https://doi.org/10.19746/j.cnki.issn.1009-2137.2019.06.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31839062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31839062"}]}]}]}
Synonyms HSA-MIR-609, MIRN609
NCBI Gene ID 693194
API
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Predicted Functions View MIR609's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR609's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR609's ARCHS4 Predicted Functions.

Functional Associations

MIR609 has 241 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR609 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR609 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR609 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR609 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR609 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR609 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR609 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR609 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR609 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR609 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR609 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR609 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.