MIR610 Gene

HGNC Family Non-coding RNAs
Name microRNA 610
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‑610 is emerging as an important tumor‐suppressive microRNA that exerts its anti‑oncogenic effects by directly targeting key regulators of cell migration, invasion, and proliferation. In gastric cancer, for example, miR‑610 is downregulated following epidermal growth factor stimulation, which normally upregulates VASP – a promoter of cell migration and invasion. miR‑610 directly binds to the 3′‑UTR of VASP mRNA, thereby inhibiting its expression and reducing the migratory and invasive capabilities of tumor cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in gastric cancer, miR‑610 has been implicated in hematological and brain malignancies. In multiple myeloma, the oncogenic lncRNA FEZF1‑AS1 acts as a competing endogenous RNA that sequesters miR‑610, thereby promoting Akt3 expression and enhancing cell proliferation. Similarly, studies in glioblastoma and glioma reveal that miR‑610 is markedly downregulated compared to normal tissues, and its restoration blocks tumor cell proliferation, migration, and invasion by directly targeting key regulators such as cyclin D2 (CCND2), AKT3, and MDM2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, research in oral squamous cell carcinoma underscores the broad tumor‑suppressive role of miR‑610, highlighting its potential as a target for novel therapeutic strategies. By counteracting oncogenic pathways across various cancer types, miR‑610 represents a promising candidate for interventions aimed at curbing tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jing Wang, Jingwei Zhang, Junzhu Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-610 inhibits the migration and invasion of gastric cancer cells by suppressing the expression of vasodilator-stimulated phosphoprotein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cancer (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejca.2011.11.026"}], "href": "https://doi.org/10.1016/j.ejca.2011.11.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22189055"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22189055"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaomei Mo, Qian Cao, Hui Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-610 suppresses the proliferation of human glioblastoma cells by repressing CCND2 and AKT3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2016.4760"}], "href": "https://doi.org/10.3892/mmr.2016.4760"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26782072"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26782072"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yu Yan, Yong Peng, Yangzhu Ou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-610 is downregulated in glioma cells, and inhibits proliferation and motility by directly targeting MDM2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2016.5559"}], "href": "https://doi.org/10.3892/mmr.2016.5559"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27485527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27485527"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Qian-Yu Li, Li Chen, Ning Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA FEZF1-AS1 promotes cell growth in multiple myeloma via miR-610/Akt3 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.04.094"}], "href": "https://doi.org/10.1016/j.biopha.2018.04.094"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29864963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29864963"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "L-X Yao, J Liu, L Xu "}, {"type": "b", "children": [{"type": "t", "text": "MiR-610 functions as a tumor suppressor in oral squamous cell carcinoma by directly targeting AGK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201901_16764"}], "href": "https://doi.org/10.26355/eurrev_201901_16764"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30657560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30657560"}]}]}]}
Synonyms HSA-MIR-610, MIRN610
NCBI Gene ID 693195
API
Download Associations
Predicted Functions View MIR610's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR610's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR610's ARCHS4 Predicted Functions.

Functional Associations

MIR610 has 218 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR610 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR610 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR610 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR610 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR610 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR610 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR610 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR610 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR610 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR610 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR610 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR610 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR610 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.