{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent analyses of purine and pyrimidine organization in non‐coding RNAs hint that miRNAs, including MIR6124, may play specialized roles in gene regulation. In one study across primates and rodents, the authors quantified the non‐random distribution of nucleotide classes in miRNAs using metrics such as fractal dimension, Hurst exponent, Hamming distance, density distribution, and Shannon entropy to identify distinct clustering patterns. Although the study did not detail individual functional assays for MIR6124, its inclusion within this group of miRNAs that deviate significantly from random nucleotide arrangements implies that its unique purine–pyrimidine pattern may influence its secondary structure and, in turn, its regulatory interactions with target mRNAs. These findings suggest that the inherent sequence organization of MIR6124 could be crucial for its role in post‐transcriptional gene regulation across species."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jayanta Kumar Das, Pabitra Pal Choudhury, Adwitiya Chaudhuri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of Purines and Pyrimidines distribution over miRNAs of Human, Gorilla, Chimpanzee, Mouse and Rat."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-28289-x"}], "href": "https://doi.org/10.1038/s41598-018-28289-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29967426"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29967426"}]}]}]}