{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have underscored the urgent need for reliable biomarkers to predict cisplatin‐induced nephrotoxicity in cancer patients, as no such marker is currently available."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " \n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence points to the microRNA MIR6125 as a potential candidate in filling this critical gap. Although its precise mechanism remains to be fully elucidated, MIR6125 appears to modulate key gene expression pathways that may influence kidney cell responses to cisplatin, thereby impacting the susceptibility to nephrotoxic injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThese findings suggest that MIR6125 could serve as a prognostic biomarker for identifying patients at elevated risk for cisplatin-induced renal toxicity. Future research is warranted to validate its functional role and assess its clinical utility in guiding personalized therapeutic strategies and minimizing renal damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Julia C F Quintanilha, Maria A Cursino, Jessica B Borges, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity in patients with head and neck cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-021-08317-2"}], "href": "https://doi.org/10.1186/s12885-021-08317-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34011306"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34011306"}]}]}]}