MIR614 Gene

HGNC Family Non-coding RNAs
Name microRNA 614
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‑614 has emerged as an oncogenic microRNA that modulates various aspects of tumor cell behavior. In ovarian cancer cells, increased miR‑614 expression promotes cell proliferation and suppresses apoptosis via direct targeting of the protein PPP2R2A"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", while in lung cancer, investigations have revealed that miR‑614 contributes to enhanced cell invasion and proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, elevated miR‑614 levels can reprogram cell intrinsic gene expression to favor a pro‐migratory and epithelial‐to‐mesenchymal transition phenotype. Notably, increased miR‑614 expression upregulates the EMT transcription factor Slug, and the concomitant suppression of targets such as the mitochondrial small GTPase Miro1 and the transmembrane protein TAPT1 is sufficient to enhance cell migration. Reduced TAPT1 expression is also associated with a heightened risk of relapse in breast cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to these roles in cell proliferation and migration, miR‑614 has been investigated as a circulating biomarker in gastric cancer. Studies on patient serum and on the gastric cancer cell line HGC‑27 demonstrate that aberrant miR‑614 expression influences both the invasive capacity and proliferation of cancer cells, suggesting its potential utility in both diagnostic and therapeutic settings."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jing Zhang, Dongdong Gao, Hui Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of miR-614 promotes proliferation and inhibits apoptosis in ovarian cancer by suppressing PPP2R2A expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.8714"}], "href": "https://doi.org/10.3892/mmr.2018.8714"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29532877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29532877"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fang Lv, Qi Xue "}, {"type": "b", "children": [{"type": "t", "text": "[MiR-614 inhibited lung cancer cell invasion and proliferation via targeting PSA]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhongguo Fei Ai Za Zhi (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3779/j.issn.1009-3419.2014.10.02"}], "href": "https://doi.org/10.3779/j.issn.1009-3419.2014.10.02"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25342037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25342037"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tuyen T Dang, Alec T McIntosh, Julio C Morales, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR614 Expression Enhances Breast Cancer Cell Motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22010112"}], "href": "https://doi.org/10.3390/ijms22010112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33374314"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33374314"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Fengneng Jing, Hong Li, Qiuping Gao "}, {"type": "b", "children": [{"type": "t", "text": "Expression of miR-614 in gastric cancer and its effect on invasion and proliferation of gastric cancer cells HGC-27."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J BUON (2021)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34076996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34076996"}]}]}]}
Synonyms MIRN614, HSA-MIR-614
NCBI Gene ID 693199
API
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Predicted Functions View MIR614's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR614's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR614's ARCHS4 Predicted Functions.

Functional Associations

MIR614 has 840 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.

Click the + buttons to view associations for MIR614 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR614 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR614 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR614 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR614 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR614 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR614 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR614 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR614 from the GeneSigDB Published Gene Signatures dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR614 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of MIR614 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR614 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR614 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR614 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR614 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.