MIR618 Gene

HGNC Family Non-coding RNAs
Name microRNA 618
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐618 has emerged as a key regulatory molecule whose dysregulation appears to influence the development and progression of various human disorders. In non‐Hodgkin lymphoma, for example, a transcriptome‐wide analysis identified a network of miR‐618 target genes that, when deregulated due to a stem–loop single nucleotide polymorphism (rs2682818), may contribute to follicular lymphomagenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in osteosarcoma, overexpression of the long non‐coding RNA LINC00511 promotes tumor progression by “sponging” miR‐618, thereby relieving suppression of the downstream target MAEL."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditionally, studies have demonstrated a protective role of miR‐618 in non‐neoplastic conditions. Exosomes derived from mesenchymal stem cells deliver miR‐618 to hepatic stellate cells, where miR‐618 directly targets Smad4 to inhibit cell viability and migration, thereby attenuating the progression of hepatic fibrosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In thyroid cancer cells, miR‐618 has also been investigated for its involvement in regulating malignant phenotypes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while in colorectal cancer, genetic studies have linked a variant in the miR‐618 precursor (rs2682818) with a reduced risk of disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In gastric cancer, miR‐618 functions as a tumor suppressor by targeting TGF‑β2, thereby inhibiting cell invasion and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBroader analyses have further refined our understanding of miR‐618’s clinical relevance. A meta‐analysis indicated that while the rs2682818 polymorphism does not appear to affect overall cancer risk, tissue‐specific associations—such as an increased risk in breast cancer in certain genetic models—do exist, likely reflecting alterations in miR‑618 secondary structure and mature expression levels."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In metastatic colon cancer, higher circulating levels of miR‐618 were associated with prolonged overall survival, with the AC genotype of rs2682818 further correlating with decreased cancer susceptibility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " This tumor‐suppressive role is further corroborated in studies of Hirschsprung disease, where the CA/AA rs2682818 genotypes correlated with a lower disease risk"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", and in another colorectal cancer study demonstrating that reduced miR‐618—especially in patients harboring the risk genotype—led to increased cell growth and invasiveness via loss of TIMP1 suppression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, investigations in venous malformations have not revealed any significant association between the miR‐618 rs2682818 polymorphism and disease susceptibility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Collectively, these findings highlight a multifaceted role for miR‑618, with its expression and genetic variants modulating oncogenic pathways, fibrotic progression, and developmental processes across multiple tissue types.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alan Fu, Aaron E Hoffman, Ran Liu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Long intergenic non-protein coding RNA 511 promotes the progression of osteosarcoma cells through sponging microRNA 618 to upregulate the expression of maelstrom."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.102109"}], "href": "https://doi.org/10.18632/aging.102109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31386627"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31386627"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chao Sun, Cuicui Shi, Xiaoyan Duan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal microRNA-618 derived from mesenchymal stem cells attenuate the progression of hepatic fibrosis by targeting Smad4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2023799"}], "href": "https://doi.org/10.1080/21655979.2021.2023799"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35199612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35199612"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "L Yi, Y Yuan "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-618 modulates cell growth via targeting PI3K/Akt pathway in human thyroid carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Indian J Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4103/0019-509X.186577"}], "href": "https://doi.org/10.4103/0019-509X.186577"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27453421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27453421"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yuetong Chen, Mulong Du, Wei Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphism rs2682818 in miR-618 is associated with colorectal cancer susceptibility in a Han Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.1409"}], "href": "https://doi.org/10.1002/cam4.1409"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29533012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29533012"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ji Shi, Lijie Gong, Legao Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-618 Suppresses Metastasis in Gastric Cancer by Downregulating the Expression of TGF-β2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anat Rec (Hoboken) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ar.24083"}], "href": "https://doi.org/10.1002/ar.24083"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30737902"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30737902"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xingliang Feng, Dan Ji, Chaozhao Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Does miR-618 rs2682818 variant affect cancer susceptibility? Evidence from 10 case-control studies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20190741"}], "href": "https://doi.org/10.1042/BSR20190741"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31383788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31383788"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Maria Radanova, Galya Mihaylova, Zhasmina Mihaylova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating miR-618 Has Prognostic Significance in Patients with Metastatic Colon Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/curroncol28020116"}], "href": "https://doi.org/10.3390/curroncol28020116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33804070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33804070"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yi Zheng, Tongyi Lu, Xiaoli Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-618 rs2682818 C>A polymorphism decreases Hirschsprung disease risk in Chinese children."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20193989"}], "href": "https://doi.org/10.1042/BSR20193989"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32364585"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32364585"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Wei Shao, Haina Xia, Qiangfang Lan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphism rs2682818 participates in the progression of colorectal carcinoma via miR-618-TIMP1 regulatory axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-02613-4"}], "href": "https://doi.org/10.1038/s41598-021-02613-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34848810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34848810"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Xi Lin, Zijian Chen, Guitao Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Correlation between the miR-618 rs2682818 C>A polymorphism and venous malformation susceptibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biotechnol Appl Biochem (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/bab.2618"}], "href": "https://doi.org/10.1002/bab.2618"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38804038"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38804038"}]}]}]}
Synonyms MIRN618, MIR-618, HSA-MIR-618
NCBI Gene ID 693203
API
Download Associations
Predicted Functions View MIR618's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR618's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR618's ARCHS4 Predicted Functions.

Functional Associations

MIR618 has 710 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.

Click the + buttons to view associations for MIR618 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR618 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR618 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR618 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR618 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR618 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR618 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR618 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR618 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with MIR618 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR618 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR618 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR618 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR618 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR618 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.