{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have identified miR-619-5p as a versatile post‐transcriptional regulator with broad binding affinities across numerous mRNAs, as evidenced by its high‐affinity interactions reported through large-scale bioinformatics analyses. In addition, patient plasma profiling in prostatic cancer revealed significantly increased levels of miR-619-5p, suggesting its potential as a circulating biomarker in oncologic contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn several malignancies, miR-619-5p participates in complex regulatory axes mediated by noncoding RNAs. In glioma, the long noncoding RNA BCYRN1 functions as a competing endogenous RNA (ceRNA) by sponging miR-619-5p, thereby releasing its target CUEDC2 and ultimately modulating the PTEN/AKT/p21 pathway to suppress tumorigenesis. In colorectal cancer, similar ceRNA mechanisms have been observed via lncRNA SBF2-AS1 and circular RNA FAT1 that sequester miR-619-5p, resulting in upregulation of oncogenic mediators such as HDAC3 and FOSL2, respectively. Moreover, in non-small cell lung cancer, miR-619-5p is notably enriched in tumor-derived exosomes where it enhances angiogenesis and metastasis by targeting RCAN1.4."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond oncogenesis, miR-619-5p is implicated in reproductive system disorders; in cases of polycystic ovary syndrome, for instance, upregulation of circ_BECN1 in ovarian granulosa cells promotes cell proliferation and suppresses apoptosis by sponging miR-619-5p, leading to augmented expression of Rab5b. Although a study in pancreatic cancer focused on chemoresistance mechanisms involving lncRNA PVT1 did not directly attribute a role to miR-619-5p, its inclusion in the broader network of noncoding RNA interactions underlines the molecule's multifaceted impact on cellular behavior in diverse disease settings."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anatoly Ivashchenko, Olga Berillo, Anna Pyrkova, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Plasma Levels of hsa-miR-619-5p and hsa-miR-1184 Differ in Prostatic Benign Hyperplasia and Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bull Exp Biol Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10517-016-3357-7"}], "href": "https://doi.org/10.1007/s10517-016-3357-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27265125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27265125"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Gang Chen, Yue Gu, Peng Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA SBF2-AS1 promotes colorectal cancer proliferation and invasion by inhibiting miR-619-5p activity and facilitating HDAC3 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28509"}], "href": "https://doi.org/10.1002/jcp.28509"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30912164"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30912164"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Dong Ha Kim, Sojung Park, HyeongRyul Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor-derived exosomal miR-619-5p promotes tumor angiogenesis and metastasis through the inhibition of RCAN1.4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2020.01.023"}], "href": "https://doi.org/10.1016/j.canlet.2020.01.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32004570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32004570"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Maolin Mu, Wanxiang Niu, Xiaoming Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA BCYRN1 inhibits glioma tumorigenesis by competitively binding with miR-619-5p to regulate CUEDC2 expression and the PTEN/AKT/p21 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-020-01466-x"}], "href": "https://doi.org/10.1038/s41388-020-01466-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32978519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32978519"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Wanli Ma, Zhong Niu, Dongfeng Han, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-020-01237-y"}], "href": "https://doi.org/10.1186/s12943-020-01237-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32727463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32727463"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hairui Fan, Dongjie Zhou, Xiaomei Zhang, et al. 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