MIR620 Gene

HGNC Family Non-coding RNAs
Name microRNA 620
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR-620 has emerged as an important regulatory molecule in diverse disease contexts. In lung adenocarcinoma, upregulation of miR-620 is associated with the direct suppression of the tumor suppressor gene GPC5 via binding to its 3′‐untranslated region. This downregulation contributes to enhanced cellular proliferation, migration, and invasion, underscoring its role as an oncogenic microRNA in lung cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn asthma, miR-620 is significantly upregulated in airway smooth muscle cells following TGF‑β1 stimulation. This increase drives cell proliferation and concurrently suppresses apoptosis by targeting phosphatase and tensin homolog (PTEN), which in turn activates the AKT signaling pathway. This miR‑620/PTEN/AKT axis appears to be instrumental in mediating bronchial remodeling, thereby offering a potential therapeutic target for asthma intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, in cholangiocarcinoma, exosome‐mediated delivery of circular RNA has been shown to sequester miR-620, leading to the upregulation of APAF1, a key pro-apoptotic factor. The sponging of miR‑620 by exosomal circ_0037104 results in the inhibition of tumor cell proliferation and metastasis, highlighting an additional layer of tumor suppression achievable through modulation of the miR‑620/APAF1 axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhengyuan Zhao, Chengguang Han, Juntao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GPC5, a tumor suppressor, is regulated by miR-620 in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2014.2092"}], "href": "https://doi.org/10.3892/mmr.2014.2092"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24682381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24682381"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hui Chen, Su-Xiang Guo, Sai Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiRNA-620 promotes TGF-β1-induced proliferation of airway smooth muscle cell through controlling PTEN/AKT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kaohsiung J Med Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/kjm2.12260"}], "href": "https://doi.org/10.1002/kjm2.12260"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32583575"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32583575"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zilin Yuan, Ba Xiong, Lie Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal circ_0037104 derived from Hu-MSCs inhibits cholangiocarcinoma progression by sponging miR-620 and targeting AFAP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem Mol Toxicol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbt.23656"}], "href": "https://doi.org/10.1002/jbt.23656"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38348717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38348717"}]}]}]}
Synonyms HSA-MIR-620, MIRN620
NCBI Gene ID 693205
API
Download Associations
Predicted Functions View MIR620's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR620's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR620's ARCHS4 Predicted Functions.

Functional Associations

MIR620 has 310 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR620 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR620 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR620 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR620 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR620 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR620 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR620 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR620 from the GeneSigDB Published Gene Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR620 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR620 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR620 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.