MIR621 Gene

HGNC Family Non-coding RNAs
Name microRNA 621
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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Moreover, the downregulation of miR-621, mediated by long non-coding RNA HOST2, has been implicated in the development of resistance to gefitinib, highlighting its potential as a modulator of drug sensitivity in NSCLC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn gastrointestinal malignancies, miR-621 exerts tumor-suppressive effects. In gastric adenocarcinoma, miR-621 is downregulated, and its restoration inhibits cell viability, colony formation, and proliferation by directly targeting AURKA, thereby impacting downstream GSK-3β/β-catenin signaling. In gastric cancer, miR-621 is also functionally linked to circular RNA circ_0000064 and the SYF2 pre-mRNA splicing factor, with their interplay contributing to tumor progression. Furthermore, emerging evidence in colorectal liver metastasis suggests that miR-621 may serve as a tumor suppressor, although its precise mechanisms in this context require further investigation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "J Xue, Y Chi, Y Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiRNA-621 sensitizes breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2015.96"}], "href": "https://doi.org/10.1038/onc.2015.96"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25867061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25867061"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "M Zhang, H Shi, C Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiRNA-621 inhibits the malignant progression of non-small cell lung cancer via targeting SIX4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201906_18066"}], "href": "https://doi.org/10.26355/eurrev_201906_18066"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31210312"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31210312"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Z-Y Chen, H-Y Liu, N Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA HOST2 enhances gefitinib-resistance in non-small cell lung cancer by down-regulating miRNA-621."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201911_19560"}], "href": "https://doi.org/10.26355/eurrev_201911_19560"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31799663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31799663"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiao Han, Hongxue Liu, Xiaojun Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiRNA-621 exerts tumor suppressor function in gastric adenocarcinoma by targeting AURKA/GSK-3β pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Pol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18388/abp.2020_5452"}], "href": "https://doi.org/10.18388/abp.2020_5452"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33629578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33629578"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ayiguli Hare, Min Zeng, Aizimaiti Rehemutula, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa-circ_0000064 accelerates the malignant progression of gastric cancer via sponging microRNA-621."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kaohsiung J Med Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/kjm2.12419"}], "href": "https://doi.org/10.1002/kjm2.12419"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34245111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34245111"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xinyi Chen, Jingyao Tu, Chaofan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-621 functions as a metastasis suppressor in colorectal cancer by directly targeting LEF1 and suppressing Wnt/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2022.120941"}], "href": "https://doi.org/10.1016/j.lfs.2022.120941"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36087740"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36087740"}]}]}]}
Synonyms MIRN621, HSA-MIR-621
NCBI Gene ID 693206
API
Download Associations
Predicted Functions View MIR621's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR621's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR621's ARCHS4 Predicted Functions.

Functional Associations

MIR621 has 614 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 16 datasets.

Click the + buttons to view associations for MIR621 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of MIR621 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR621 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR621 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR621 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR621 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR621 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR621 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR621 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR621 from the GeneSigDB Published Gene Signatures dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR621 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of MIR621 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR621 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR621 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of MIR621 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR621 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR621 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.