MIR623 Gene

HGNC Family Non-coding RNAs
Name microRNA 623
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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In gastric cancer, its reduced expression is associated with elevated cyclin D1 levels, while restoration of miR‑623 suppresses cell proliferation and enhances 5‑fluorouracil chemosensitivity via the apoptotic pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In pancreatic cancer, hsa‑miR‑623 directly binds the 3′‑UTR of MMP1 mRNA, leading to inhibition of MMP1 expression and downstream ERK phosphorylation, which results in decreased epithelial–mesenchymal transition, reduced invasion, and attenuated metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in hepatocellular carcinoma, miR‑623 is markedly downregulated; its overexpression suppresses cell proliferation, migration, and invasion by modulating the PI3K/Akt, Wnt/β‑catenin, and ERK/JNK signaling pathways via direct targeting of XRCC5."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in breast cancer, miR‑623 is postulated to function as a tumor suppressor, reinforcing its emerging importance in oncogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in cancer, miR‑623 is implicated in non‑malignant pathologies. In intervertebral disc degeneration, oxidative stress downregulates miR‑623; however, hypoxia‑inducible factor‑1α (HIF‑1α) can directly bind to its promoter and induce its expression. Elevated miR‑623, in turn, alleviates apoptosis and inflammatory responses in nucleus pulposus cells through direct targeting of thioredoxin‑interacting protein (TXNIP), suggesting its protective function in degenerative disc disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, bioinformatic analyses predict that in glioblastoma, miR‑623 may be targeted by the long non‑coding RNA RP11‑89, which acts as a competing endogenous RNA. This interaction likely disrupts miR‑623’s suppressive effects on cyclin D1 expression, hinting at a novel regulatory axis that could impact glioblastoma tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lihua Jiang, Wenchuan Yang, Weishi Bian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-623 Targets Cyclin D1 to Inhibit Cell Proliferation and Enhance the Chemosensitivity of Cells to 5-Fluorouracil in Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504018X15193469240508"}], "href": "https://doi.org/10.3727/096504018X15193469240508"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29495973"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29495973"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yutong Chen, Siqi Peng, Hong Cen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA hsa-miR-623 directly suppresses MMP1 and attenuates IL-8-induced metastasis in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2019.4803"}], "href": "https://doi.org/10.3892/ijo.2019.4803"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31115512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31115512"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Feng Ren, Hui Su, Haitao Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of miR-623 suppresses progression of hepatocellular carcinoma via regulating the PI3K/Akt signaling pathway by targeting XRCC5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29117"}], "href": "https://doi.org/10.1002/jcb.29117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31190447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31190447"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Qing Li, Jiangtao Liu, Yanli Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-623 suppresses cell proliferation, migration and invasion through direct inhibition of XRCC5 in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103182"}], "href": "https://doi.org/10.18632/aging.103182"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32501811"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32501811"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiaogang Bao, Zhenhua Wang, Qi Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HIF-1"}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "α"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-Mediated miR-623 Regulates Apoptosis and Inflammatory Responses of Nucleus Pulposus Induced by Oxidative Stress via Targeting TXNIP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oxid Med Cell Longev (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/6389568"}], "href": "https://doi.org/10.1155/2021/6389568"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34394829"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34394829"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jiaqi Liao, Jinxian Xu, Kaiming Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-623 links lncRNA RP11-89 and cyclin D1 to regulate the proliferation of glioblastoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Neurosci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/00207454.2022.2098734"}], "href": "https://doi.org/10.1080/00207454.2022.2098734"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36066507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36066507"}]}]}]}
Synonyms HSA-MIR-623, MIRN623
NCBI Gene ID 693208
API
Download Associations
Predicted Functions View MIR623's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR623's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR623's ARCHS4 Predicted Functions.

Functional Associations

MIR623 has 663 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 13 datasets.

Click the + buttons to view associations for MIR623 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR623 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR623 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR623 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR623 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR623 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR623 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR623 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR623 from the GeneSigDB Published Gene Signatures dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR623 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR623 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR623 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR623 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR623 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.