MIR624 Gene

HGNC Family Non-coding RNAs
Name microRNA 624
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nStudies indicate that MIR624 plays context‐dependent roles in tumor biology. In human chondrosarcoma, for instance, BDNF was found to promote lymphangiogenesis and metastatic spread by downregulating miR‑624‑3p, thereby releasing the inhibition on VEGF‑C production. This finding suggests that miR‑624‑3p normally acts to suppress lymphangiogenic signaling in these tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn osteosarcoma, aberrant expression of miR‑624‑5p has been associated with disease progression, implicating a role for this microRNA in osteosarcoma development. Although detailed mechanisms remain to be fully elucidated, these observations point to miR‑624‑5p as an important regulator in the pathogenesis of osteosarcoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nConversely, in ovarian cancer cells resistant to chemotherapy, high levels of miR‑624‑5p were recorded; this upregulation appears to boost cell viability and reinforce drug resistance, indicating a potential oncogenic function of miR‑624‑5p in this context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma, the overexpression of a circular RNA (circ_0006404) was shown to sponge miR‑624, leading to its downregulation. This depletion of miR‑624 corresponded with enhanced cell growth, accelerated cell cycle progression, and increased migration, suggesting that miR‑624 may normally function as a tumor suppressor in liver cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chih-Yang Lin, Shih-Wei Wang, Yen-Ling Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brain-derived neurotrophic factor promotes VEGF-C-dependent lymphangiogenesis by suppressing miR-624-3p in human chondrosarcoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2017.354"}], "href": "https://doi.org/10.1038/cddis.2017.354"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28771226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28771226"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yongjun Luo, Wei Liu, Pengyu Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-624-5p promoted tumorigenesis and metastasis by suppressing hippo signaling through targeting PTPRB in osteosarcoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-019-1491-6"}], "href": "https://doi.org/10.1186/s13046-019-1491-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31829261"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31829261"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "May Mohammed Alrashed, Homood Alharbi, Abdualrahman Saeed Alshehry, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-624-5p enhances NLRP3 augmented gemcitabine resistance via EMT/IL-1β/Wnt/β-catenin signaling pathway in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Reprod Immunol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jri.2022.103488"}], "href": "https://doi.org/10.1016/j.jri.2022.103488"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35124344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35124344"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Liguo Zhang, Ping Zhang, Tonggang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0006404 enhances hepatocellular carcinoma progression by regulating miR-624."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Sci Pollut Res Int (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11356-021-17574-4"}], "href": "https://doi.org/10.1007/s11356-021-17574-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35579835"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35579835"}]}]}]}
Synonyms HSA-MIR-624, MIRN624, MIR-624
NCBI Gene ID 693209
API
Download Associations
Predicted Functions View MIR624's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR624's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR624's ARCHS4 Predicted Functions.

Functional Associations

MIR624 has 237 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.

Click the + buttons to view associations for MIR624 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR624 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR624 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR624 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR624 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR624 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR624 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR624 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR624 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR624 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR624 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR624 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR624 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR624 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR624 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.