MIR627 Gene

HGNC Family Non-coding RNAs
Name microRNA 627
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that miR‐627 plays versatile roles in human disease. Although one study investigated circulating miRNAs as diagnostic markers for gastric cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", accumulating evidence indicates that miR‐627 regulates key cellular processes in both metabolic disorders and fibrotic conditions. For example, in non‐alcoholic fatty liver disease, exosomal miR‐627‑5p derived from human umbilical cord mesenchymal stem cells promotes hepatocyte viability and curbs apoptosis by targeting FTO, thereby improving glucose and lipid metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In pulmonary fibrosis, miR‐627 directly targets HMGB1 to disrupt NF‑κB activation and TGF‑β1–induced expression of fibrotic markers"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", while reduced miR‐627 expression in hypertrophic scar tissue permits increased IGF‑1 levels that drive fibroblast proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer, miR‑627 functions predominantly as a tumor suppressor. In glioma, downregulation of miR‑627‑5p—secondary to its sequestration by the long noncoding RNA UCA1—leads to enhanced expression of the oncogenic transcriptional coactivator NR2C2 and promotes malignant behaviors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Similarly, in hepatocellular carcinoma, decreased miR‑627‑5p levels are associated with increased tumor size and advanced stage, with restoration of miR‑627‑5p suppressing cell proliferation by targeting BCL3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In gastric cancer, a polymorphism in the miR‑627 gene (rs2620381) has been linked to an increased risk of disease, underlining its importance in tumor pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Additionally, in lung carcinoma, miR‑627‑3p is inhibited by lncRNA RP11‑284F21.9, resulting in increased expression of the cell division cycle and apoptosis regulator CCAR1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "; in ovarian cancer, the lncRNA LOC646029 sponges miR‑627‑3p thereby promoting metastasis via upregulation of a suppressor of KRAS signaling"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "; and in colon cancer, LBX2‑AS1 acts as a competing endogenous RNA to sequester miR‑627‑5p, which normally represses the oncogenic RAC1/PI3K/AKT pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these findings underscore the multifaceted role of miR‑627—from serving as a potential diagnostic biomarker"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "to modulating metabolic homeostasis, fibrotic responses, and tumorigenesis via diverse targets and interacting noncoding RNAs. The emerging regulatory networks involving miR‑627 offer promising avenues for therapeutic intervention and prognostic evaluation across a wide range of pathological conditions.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Vivian Yvonne Shin, Enders K O Ng, Vivian W Chan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A three-miRNA signature as promising non-invasive diagnostic marker for gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-015-0473-3"}], "href": "https://doi.org/10.1186/s12943-015-0473-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26607322"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26607322"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lidan Cheng, Peng Yu, Fangfang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human umbilical cord-derived mesenchymal stem cell-exosomal miR-627-5p ameliorates non-alcoholic fatty liver disease by repressing FTO expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-021-00593-1"}], "href": "https://doi.org/10.1007/s13577-021-00593-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34410623"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34410623"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jie Li, Xinyi Kong, Shanshan Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-627/HMGB1/NF-κB regulatory loop modulates TGF-β1-induced pulmonary fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27038"}], "href": "https://doi.org/10.1002/jcb.27038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30536600"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30536600"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jie Li, Xueyu Zhang, Tao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The MIR155 host gene/microRNA-627/HMGB1/NF-κB loop modulates fibroblast proliferation and extracellular matrix deposition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2021.119085"}], "href": "https://doi.org/10.1016/j.lfs.2021.119085"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33482190"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33482190"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "B Y Guo, F Lin, Q Hui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Expression and effect of microRNA-627 in human hypertrophic scar]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Shao Shang Za Zhi (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.cn501120-20200225-00090"}], "href": "https://doi.org/10.3760/cma.j.cn501120-20200225-00090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33887883"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33887883"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zirong Fan, Jian Zheng, Yixue Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NR2C2-uORF targeting UCA1-miR-627-5p-NR2C2 feedback loop to regulate the malignant behaviors of glioma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-1149-x"}], "href": "https://doi.org/10.1038/s41419-018-1149-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30518750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30518750"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jun Wang, Tianxiang Chen, Liang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-627-5p inhibits the proliferation of hepatocellular carcinoma cells by targeting BCL3 transcription coactivator."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Pharmacol Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1440-1681.13218"}], "href": "https://doi.org/10.1111/1440-1681.13218"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31793036"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31793036"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "M Raad, Z Salehi, M Habibzaadeh Baalsini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of rs2620381 polymorphism in miR-627 and gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Biomed Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/09674845.2019.1692762"}], "href": "https://doi.org/10.1080/09674845.2019.1692762"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31983284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31983284"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Dan Li, Li Wang, Jin Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RP11‑284F21.9 promotes lung carcinoma proliferation and invasion via the regulation of miR‑627‑3p/CCAR1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2020.7732"}], "href": "https://doi.org/10.3892/or.2020.7732"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32945522"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32945522"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Pengfei Zhao, Yating Wang, Xiao Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Med (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11684-023-1004-z"}], "href": "https://doi.org/10.1007/s11684-023-1004-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37434064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37434064"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jing Fang, Junyuan Yang, Hui Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LBX2-AS1 predicts poor survival of colon cancer patients and promotes its progression via regulating miR-627-5p/RAC1/PI3K/AKT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-022-00745-x"}], "href": "https://doi.org/10.1007/s13577-022-00745-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35816228"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35816228"}]}]}]}
Synonyms MIRN627, MIR-627, HSA-MIR-627
NCBI Gene ID 693212
API
Download Associations
Predicted Functions View MIR627's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR627's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR627's ARCHS4 Predicted Functions.

Functional Associations

MIR627 has 195 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR627 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR627 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR627 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR627 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR627 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR627 from the GeneSigDB Published Gene Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR627 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR627 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR627 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR627 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.