MIR631 Gene

HGNC Family Non-coding RNAs
Name microRNA 631
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR-631 acts as a critical regulator in cancer by directly modulating key effectors that drive aggressive cellular behaviors. In prostate cancer, miR-631 binds to the 3′‐untranslated region of ZAP70, reducing its expression and thereby impeding cell migration and invasion. Similarly, in multiple myeloma, decreased miR-631 levels lead to an upregulation of its target UbcH10, which in turn enhances the expression of MDR1 and promotes resistance to bortezomib. Overexpressing miR-631 in these resistant cells restores drug sensitivity and increases apoptosis, underscoring its potential as a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the setting of nonalcoholic fatty liver disease (NAFLD), although the study primarily focuses on the lncRNA CCAT1 and its sponging effect on miR-613 to promote LXRα transcription and lipid droplet formation, interactions between miR-631, CCAT1, and LXRα were also validated. This finding suggests that miR-631 might participate in the regulatory network controlling hepatic lipid metabolism, even though its direct functional consequence in NAFLD remains to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn chondrosarcoma, reduced miR-631 expression is linked to the activation of the apelin (APLN) pathway, contributing to resistance against the chemotherapeutic agent doxorubicin. Restoration of miR-631 levels in resistant chondrosarcoma cells significantly enhances doxorubicin sensitivity, highlighting its role in modulating drug response through the suppression of APLN expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dewang Fu, Ben Liu, Li E Zang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-631/ZAP70: A novel axis in the migration and invasion of prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.11.093"}], "href": "https://doi.org/10.1016/j.bbrc.2015.11.093"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26620225"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26620225"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hao Xi, Lu Li, Juan Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hsa-miR-631 resensitizes bortezomib-resistant multiple myeloma cell lines by inhibiting UbcH10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.5318"}], "href": "https://doi.org/10.3892/or.2016.5318"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28000886"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28000886"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Feizhou Huang, Huaizheng Liu, Zhao Lei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA CCAT1 inhibits miR-613 to promote nonalcoholic fatty liver disease via increasing LXRα transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29795"}], "href": "https://doi.org/10.1002/jcp.29795"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32413192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32413192"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jui-Chieh Chen, Hsun-Chang Shih, Chih-Yang Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-631 Resensitizes Doxorubicin-Resistant Chondrosarcoma Cells by Targeting Apelin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms24010839"}], "href": "https://doi.org/10.3390/ijms24010839"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36614283"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36614283"}]}]}]}
Synonyms HSA-MIR-631, MIRN631
NCBI Gene ID 693216
API
Download Associations
Predicted Functions View MIR631's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR631's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR631's ARCHS4 Predicted Functions.

Functional Associations

MIR631 has 304 functional associations with biological entities spanning 6 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 16 datasets.

Click the + buttons to view associations for MIR631 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR631 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR631 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR631 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR631 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR631 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR631 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR631 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GAD Gene-Disease Associations diseases associated with MIR631 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR631 from the GeneSigDB Published Gene Signatures dataset.
GTEx eQTL SNPs regulating expression of MIR631 gene from the GTEx eQTL dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR631 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with MIR631 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR631 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR631 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR631 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR631 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.