MIR632 Gene

HGNC Family Non-coding RNAs
Name microRNA 632
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that miR-632 acts as a potent oncogenic regulator in a variety of cancers. Elevated miR-632 levels promote tumor progression by downregulating key tumor‐suppressive genes. For example, in breast cancer, miR-632 targets the coding region of DNAJB6, leading to enhanced invasion and metastatic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In laryngeal carcinoma, overexpressed miR-632 suppresses glycogen synthase kinase 3β (GSK3β), thereby accelerating proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in gastric cancer, miR-632 has been shown to promote disease progression in a trefoil factor 1 (TFF1)–dependent manner"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", and in hepatocellular carcinoma it targets MYCT1 to foster cell growth and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In rectal cancer, the long non-coding RNA FEZF1-AS1 functions as a competing endogenous RNA that sequesters miR-632, thereby modulating the expression of FAM83A and contributing to oncogenic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In addition, a circular RNA, circ1811, exerts tumor‐suppressive effects in gastric cancer by sponging miR-632 to upregulate DAPK1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n\nDiscerning further multifaceted roles, miR-632 has also emerged as a candidate biomarker and pathogenic mediator in non-oncologic contexts. In a cohort of patients undergoing maintenance hemodialysis, altered circulating miR-632 levels were associated with cardiovascular risk patterns, suggesting its prognostic utility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, in Marfan syndrome aortopathy, upregulation of miR-632 was found to suppress DNAJB6 in the aortic wall, thereby activating Wnt/β-catenin signaling and promoting endothelial-to-mesenchymal transition and fibrosis, processes that contribute to vascular deterioration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n \n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Aparna Mitra, Jack W Rostas, Donna L Dyess, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Micro-RNA-632 downregulates DNAJB6 in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lab Invest (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/labinvest.2012.87"}], "href": "https://doi.org/10.1038/labinvest.2012.87"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22710984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22710984"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhong-Xin Zhou, Zu-Ping Zhang, Ze-Zhang Tao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-632 Promotes Laryngeal Carcinoma Cell Proliferation, Migration, and Invasion Through Negative Regulation of GSK3β."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504018X15213142076069"}], "href": "https://doi.org/10.3727/096504018X15213142076069"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29562960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29562960"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ying Shi, Xiaoxiao Huang, Guobin Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-632 promotes gastric cancer progression by accelerating angiogenesis in a TFF1-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-018-5247-z"}], "href": "https://doi.org/10.1186/s12885-018-5247-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30612555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30612555"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jian Pu, Jianchu Wang, Zuoming Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-632 Functions as Oncogene in Hepatocellular Carcinoma via Targeting MYCT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Gene Ther Clin Dev (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/humc.2019.040"}], "href": "https://doi.org/10.1089/humc.2019.040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30982352"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30982352"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Rongjun Xie, Chubao Liu, Longfei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA FEZF1-AS1 promotes rectal cancer progression by competitively binding miR-632 with FAM83A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3724/abbs.2022022"}], "href": "https://doi.org/10.3724/abbs.2022022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35607960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35607960"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Min Fu, Jianmei Gu, Dan Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ1811 suppresses gastric cancer progression by regulating the miR-632/DAPK1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2024.148331"}], "href": "https://doi.org/10.1016/j.gene.2024.148331"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38438055"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38438055"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "David de Gonzalo-Calvo, Pablo Martínez-Camblor, Christian Bär, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Improved cardiovascular risk prediction in patients with end-stage renal disease on hemodialysis using machine learning modeling and circulating microribonucleic acids."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.46123"}], "href": "https://doi.org/10.7150/thno.46123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32754270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32754270"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sonia Terriaca, Maria Giovanna Scioli, Calogera Pisano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-632 Induces DNAJB6 Inhibition Stimulating Endothelial-to-Mesenchymal Transition and Fibrosis in Marfan Syndrome Aortopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms242015133"}], "href": "https://doi.org/10.3390/ijms242015133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37894814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37894814"}]}]}]}
Synonyms HSA-MIR-632, MIRN632
NCBI Gene ID 693217
API
Download Associations
Predicted Functions View MIR632's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR632's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR632's ARCHS4 Predicted Functions.

Functional Associations

MIR632 has 1,302 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 17 datasets.

Click the + buttons to view associations for MIR632 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of MIR632 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR632 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR632 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR632 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR632 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR632 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR632 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR632 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR632 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR632 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of MIR632 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR632 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR632 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR632 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of MIR632 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR632 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR632 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.