MIR634 Gene

HGNC Family Non-coding RNAs
Name microRNA 634
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐634 (miR‑634) has emerged as a multifaceted tumor suppressor across a variety of malignancies. In esophageal, cervical, gastric, hepatocellular, nasopharyngeal, glioma, and tongue cancers, miR‑634 is frequently downregulated. Restoration or overexpression of miR‑634 induces apoptosis and reduces cell proliferation, migration, and invasion by targeting key oncogenic pathways. For example, enforced miR‑634 expression activates the mitochondrial apoptotic pathway via concurrent targeting of genes involved in mitochondrial homeostasis, antiapoptosis, antioxidant defense, and autophagy; it is also capable of suppressing the mTOR signaling pathway and downregulating targets such as JAG1, Rab1A, DHX33, and MAP2K4. Moreover, in several tumor types, competitive endogenous RNAs—including circular RNAs and long noncoding RNAs (e.g., DANCR and circRNAs)—sequester miR‑634, thereby derepressing oncogenic targets (such as GRB2) and contributing to chemoresistance and tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its tumor‐suppressive actions, miR‑634 plays important regulatory roles in non‐malignant conditions. In osteoarthritis, for instance, elevated miR‑634 levels in high‑grade chondrocytes suppress cell survival and matrix synthesis via direct targeting of PIK3R1, leading to reduced activation of the Akt/mTOR/S6 signaling axes. Similarly, in inflammatory vascular disorders such as ANCA‑associated vasculitis, increased miR‑634 in monocyte‑derived macrophages promotes a proinflammatory phenotype by enhancing ADAM17 and IL‑6 expression. Furthermore, in the context of hypertension, miR‑634 is downregulated in human aortic smooth muscle cells; its enforced expression inhibits Ang II–induced proliferation and migration by directly targeting Wnt4 and blocking β‑catenin nuclear translocation. Finally, the localization of miR‑634 within an intron of the PRKCA gene hints at its broader involvement in susceptibility to diverse inflammatory and neuropsychiatric conditions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaowei Peng, Peiguo Cao, Dong He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-634 sensitizes nasopharyngeal carcinoma cells to paclitaxel and inhibits cell growth both in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2014)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25400759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25400759"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Naoto Fujiwara, Jun Inoue, Tatsuyuki Kawano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-634 Activates the Mitochondrial Apoptosis Pathway and Enhances Chemotherapy-Induced Cytotoxicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-15-0257"}], "href": "https://doi.org/10.1158/0008-5472.CAN-15-0257"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26216549"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26216549"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jianglin Cong, Riming Liu, Xuan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-634 decreases cell proliferation and induces apoptosis by targeting mTOR signaling pathway in cervical cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Artif Cells Nanomed Biotechnol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/21691401.2015.1080171"}], "href": "https://doi.org/10.3109/21691401.2015.1080171"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26367112"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26367112"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chris Zhiyi Zhang, Yun Cao, Jia Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-634 exhibits anti-tumor activities toward hepatocellular carcinoma via Rab1A and DHX33."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molonc.2016.09.001"}], "href": "https://doi.org/10.1016/j.molonc.2016.09.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27693040"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27693040"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Dawei Xu, Jian Yu, Guojun Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA DANCR functions as a competing endogenous RNA to regulate RAB1A expression by sponging miR-634 in glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20171664"}], "href": "https://doi.org/10.1042/BSR20171664"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29301870"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29301870"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jiao Guo, Chun-Dong Zhang, Jia-Xiang An, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of miR-634 in gastric carcinoma and its effects on proliferation, migration, and invasion of gastric cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.1204"}], "href": "https://doi.org/10.1002/cam4.1204"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29464926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29464926"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Beibei Shao, Longlong He "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0001742 promotes tongue squamous cell carcinoma progression via modulating miR-634 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.03.122"}], "href": "https://doi.org/10.1016/j.bbrc.2019.03.122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30944081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30944081"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xubin Ren, Nie Xu, Yunting Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of long non-coding RNA ZXF1 restricts cell survival by targeting miR-634-GRB2 in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Pol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18388/abp.2020_2875"}], "href": "https://doi.org/10.18388/abp.2020_2875"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32160453"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32160453"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Du Tian-Zhao, Yang Yang, Wang Xing-Xuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Profiling of circular RNAs and circTPCN/miR-634/mTOR regulatory pathway in cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygeno.2021.05.026"}], "href": "https://doi.org/10.1016/j.ygeno.2021.05.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34029698"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34029698"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Chao Pan, Zhijian Su, Honghui Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0081069 facilitates tongue squamous cell carcinoma progression by modulating MAP2K4 expression via miR-634."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Odontology (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10266-022-00746-0"}], "href": "https://doi.org/10.1007/s10266-022-00746-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36181561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36181561"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Anna Bertram, Svjetlana Lovric, Alissa Engel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating ADAM17 Level Reflects Disease Activity in Proteinase-3 ANCA-Associated Vasculitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2014050477"}], "href": "https://doi.org/10.1681/ASN.2014050477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25788529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25788529"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Xu Cui, Shaojie Wang, Heguo Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of microRNA-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting PIK3R1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep23117"}], "href": "https://doi.org/10.1038/srep23117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26972586"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26972586"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Elvezia Maria Paraboschi, Giulia Cardamone, Valeria Rimoldi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-634 is a Pol III-dependent intronic microRNA regulating alternative-polyadenylated isoforms of its host gene PRKCA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Gen Subj (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagen.2017.02.016"}], "href": "https://doi.org/10.1016/j.bbagen.2017.02.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28212793"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28212793"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ligang Niu, Na Sun, Lingheng Kong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-634 inhibits human vascular smooth muscle cell proliferation and migration in hypertension through Wnt4/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Biosci (Landmark Ed) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.52586/4953"}], "href": "https://doi.org/10.52586/4953"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34455769"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34455769"}]}]}]}
Synonyms HSA-MIR-634, MIRN634
NCBI Gene ID 693219
API
Download Associations
Predicted Functions View MIR634's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR634's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR634's ARCHS4 Predicted Functions.

Functional Associations

MIR634 has 220 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR634 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR634 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR634 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR634 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR634 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR634 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR634 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR634 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR634 from the GeneSigDB Published Gene Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR634 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR634 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR634 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.