MIR636 Gene

HGNC Family Non-coding RNAs
Name microRNA 636
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‐636 is emerging as a context‐dependent regulator with distinct roles in tumorigenesis and inflammation. In hepatocellular carcinoma, suppression of ANT2 led to a marked upregulation of miR‐636, which in turn reduced cell proliferation and colony formation by decreasing Ras expression and inactivating its downstream signaling, thereby acting as a tumor suppressor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In cystic fibrosis, increased expression of miR‐636 in airway epithelial cells reduced levels of key pro‐inflammatory mediators, including IL1R1 and IKBKB, resulting in decreased NF‑κB activity and lower secretion of inflammatory cytokines."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, miR‐636 exhibits oncogenic properties in other cancer types. In bladder cancer, miR‐636 promotes cell proliferation by downregulating KLF9, and its sequestration by the circular RNA circPTPRA restores KLF9 levels and thereby suppresses proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in cervical cancer, reduced miR‐636 expression correlates with enhanced proliferation and survival via increased expression of targets such as CDK6 and Bcl‐2, indicating that in this context, restoration of miR‐636 functions to inhibit tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, in prostate adenocarcinoma with bone metastasis, miR‐636 appears to function as an oncogene by promoting cellular invasion and migration through targeting molecules like MBNL2, TNS1, and STAB1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In non‐small cell lung cancer, increased expression of the circular RNA circ_0025039 sequesters miR‐636, leading to elevated levels of its target, CORO1C, which facilitates malignant progression; conversely, circ_0025039 silencing releases miR‐636 to repress CORO1C expression and inhibit tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ji-Young Jang, Young-Sin Lee, Yoon-Kyung Jeon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emm.2013.1"}], "href": "https://doi.org/10.1038/emm.2013.1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23306701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23306701"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Pauline Bardin, Tobias Foussignière, Nathalie Rousselet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-636: A Newly-Identified Actor for the Regulation of Pulmonary Inflammation in Cystic Fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2019.02643"}], "href": "https://doi.org/10.3389/fimmu.2019.02643"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31803183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31803183"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qingqing He, Lifang Huang, Dong Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircPTPRA acts as a tumor suppressor in bladder cancer by sponging miR-636 and upregulating KLF9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.102530"}], "href": "https://doi.org/10.18632/aging.102530"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31821171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31821171"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Qing-Lan Hu, Zun-Peng Xu, Yun-Fei Lan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-636 represses cell survival by targeting CDK6/Bcl-2 in cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kaohsiung J Med Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/kjm2.12181"}], "href": "https://doi.org/10.1002/kjm2.12181"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31889428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31889428"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhiguo Zhu, Yaoan Wen, Chunxiang Xuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identifying the key genes and microRNAs in prostate cancer bone metastasis by bioinformatics analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Open Bio (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/2211-5463.12805"}], "href": "https://doi.org/10.1002/2211-5463.12805"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32027093"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32027093"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lei Wang, Cimei Zeng, Zhongren Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0025039 acts an oncogenic role in the progression of non-small cell lung cancer through miR-636-dependent regulation of CORO1C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-021-04320-0"}], "href": "https://doi.org/10.1007/s11010-021-04320-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35034254"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35034254"}]}]}]}
Synonyms MIRN636, HSA-MIR-636
NCBI Gene ID 693221
API
Download Associations
Predicted Functions View MIR636's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR636's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR636's ARCHS4 Predicted Functions.

Functional Associations

MIR636 has 1,825 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 18 datasets.

Click the + buttons to view associations for MIR636 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR636 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR636 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR636 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR636 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR636 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR636 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR636 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR636 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR636 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR636 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR636 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of MIR636 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR636 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR636 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of MIR636 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR636 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR636 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
WikiPathways Pathways 2014 pathways involving MIR636 protein from the Wikipathways Pathways 2014 dataset.