MIR639 Gene

HGNC Family Non-coding RNAs
Name microRNA 639
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR-639 has emerged as an important regulator in cancer progression with context-dependent roles. In tongue squamous cell carcinoma (TSCC), treatment with transforming growth factor‑β results in significant downregulation of miR-639, leading to enhanced expression of the transcription factor FOXC1. This decrease facilitates the epithelial-to-mesenchymal transition (EMT), thereby promoting metastasis and correlating with poor patient survival. Conversely, restoring miR-639 expression effectively blocks the TGF‑β‑induced EMT process, highlighting its potential as a therapeutic target in TSCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn thyroid carcinoma, miR-639 is markedly upregulated. Rather than suppressing tumor progression, its overexpression here acts in an oncogenic manner by promoting cell proliferation and cell cycle progression. Functional studies have demonstrated that miR-639 targets CDKN1A, a key cell cycle regulator, thereby indirectly upregulating CyclinE and c‑myc, which further drives tumor cell growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, in hepatocellular carcinoma (HCC), miR-639 is found to be downregulated in tumor tissues compared to adjacent normal liver tissues. In this context, miR-639 functions as a tumor suppressor by inhibiting cell proliferation and EMT. Mechanistic investigations revealed that miR-639 directly targets the histone acetyltransferase gene KAT7, thereby dampening the KAT7/Wnt/β‑catenin signaling pathway and reducing tumor aggressiveness – a profile that correlates with improved overall survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhaoyu Lin, Lijuan Sun, Weiliang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-639 regulates transforming growth factor beta-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting FOXC1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.12499"}], "href": "https://doi.org/10.1111/cas.12499"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25130698"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25130698"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shang-Tong Lei, Fei Shen, Ji-Wei Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-639 promoted cell proliferation and cell cycle in human thyroid cancer by suppressing CDKN1A expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2016.10.087"}], "href": "https://doi.org/10.1016/j.biopha.2016.10.087"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27829546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27829546"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhijie Bai, Xiaopu Xia, Jianfeng Lu "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-639 is Down-Regulated in Hepatocellular Carcinoma Tumor Tissue and Inhibits Proliferation and Migration of Human Hepatocellular Carcinoma Cells Through the KAT7/Wnt/β-Catenin Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.919241"}], "href": "https://doi.org/10.12659/MSM.919241"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31955177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31955177"}]}]}]}
Synonyms HSA-MIR-639, MIRN639
NCBI Gene ID 693224
API
Download Associations
Predicted Functions View MIR639's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR639's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR639's ARCHS4 Predicted Functions.

Functional Associations

MIR639 has 1,289 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 16 datasets.

Click the + buttons to view associations for MIR639 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of MIR639 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR639 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR639 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR639 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR639 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR639 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR639 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR639 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR639 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of MIR639 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR639 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR639 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR639 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of MIR639 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR639 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR639 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.