{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‐641 is emerging as a multifunctional regulator implicated in several human diseases. In lung cancer, for example, miR‐641 is downregulated and its overexpression can inhibit cell proliferation and induce apoptosis via targeting MDM2 and upregulating p53, while in certain non–small‐cell lung cancer (NSCLC) contexts, increased miR‐641 expression—by directly targeting NF1 and activating ERK signaling—contributes to acquired resistance to EGFR‐targeted therapies. Furthermore, deregulation of the CRNDE/miR‐641/CDK6 axis in NSCLC supports its role as a negative regulator of cell growth and survival."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn other cancer types, miR‐641 functions in a context‐dependent manner. In cervical cancer, elevated levels of miR‐641 promote migration and invasion by modulating the TUSC8/PTEN axis. Likewise, in cholangiocarcinoma and bladder cancer, circular RNAs (CDR1as and circSETD3, respectively) sponge miR‐641, thereby attenuating its suppression of key oncogenic pathways such as AKT/mTOR or releasing inhibition of PTEN, which suggests an oncogenic contribution of endogenous miR‐641 in these settings. In breast cancer, studies have demonstrated that miR‐641 exerts tumor‐suppressive effects by targeting molecules such as SRCAP and RRS1; its activity is modulated by competing endogenous RNAs like LINC00665 and SNHG1, where sponging of miR‐641 reverses its growth‐inhibitory roles."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond oncogenesis, miR‐641 has been implicated in nonmalignant disorders. In ischemic stroke, ongoing investigations aim to elucidate its regulatory role in neuronal injury and repair mechanisms. Additionally, in immune thrombocytopenia (ITP), upregulation of miR‐641 in T cells leads to downregulation of targets such as STIM1 and SATB1, thereby perturbing the Th17/Treg balance and contributing to disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qinglong Kong, Nan Shu, Jun Li, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA CDR1as Exerts Oncogenic Properties Partially through Regulating MicroRNA 641 in Cholangiocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00042-20"}], "href": "https://doi.org/10.1128/MCB.00042-20"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32423991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32423991"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ying Tian, Ping Gao, Di Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circSETD3 hampers cell growth, migration, and stem cell properties in bladder cancer through sponging miR-641 to upregulate PTEN."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2021.1954758"}], "href": "https://doi.org/10.1080/15384101.2021.1954758"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34288821"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34288821"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Li Li, Da Wei, Junying Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-641 Inhibited Cell Proliferation and Induced Apoptosis by Targeting NUCKS1/PI3K/AKT Signaling Pathway in Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comput Math Methods Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/5203839"}], "href": "https://doi.org/10.1155/2022/5203839"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35069784"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35069784"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Wen Cao, Xiaojing Liu, Weijia Su, et al. 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