MIR642A Gene

HGNC Family Non-coding RNAs
Name microRNA 642a
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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In the field of oncology, miR‑642a has been identified as a member of a chemoresistance‐associated microRNA signature in serous epithelial ovarian carcinoma, suggesting its utility as a diagnostic marker for predicting treatment response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hepatocellular carcinoma, miR‑642a functions within a competing endogenous RNA network involving long noncoding RNA Linc00974 and KRT19, thereby modulating oncogenic signaling and tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in prostate cancer models, miR‑642a‑5p acts as a tumor suppressor by directly targeting key cell cycle regulators—including WT1, NUAK1, RASSF3, and SKP2—resulting in decreased tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In cervical carcinoma, downregulation of the oncogenic lncRNA PCGEM1 leads to a rise in miR‑642a‑5p levels, which in turn suppresses proliferation, migration, and invasion via modulation of LGMN expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In glioblastoma, miR‑642a‑5p is sequestered by lncRNA MAFG‑AS1; restoration of miR‑642a‑5p levels attenuates radioresistance by downregulating Notch1 signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in cancer, miR‑642a‑5p also modulates cellular responses to injury. In a sepsis‐induced cardiac injury model, reduced miR‑642a‑5p expression correlates with increased cardiomyocyte apoptosis and diminished cell viability—effects that can be reversed by replenishing miR‑642a‑5p, which directly targets ROCK1 to confer cardioprotection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In contrast, in lipopolysaccharide‑induced pulmonary microvascular endothelial cells, elevated miR‑642a‑5p levels promote hyperpermeability and apoptosis by downregulating eukaryotic elongation factor 2, thereby exacerbating lung injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Andrea Vecchione, Barbara Belletti, Francesca Lovat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A microRNA signature defines chemoresistance in ovarian cancer through modulation of angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1305472110"}], "href": "https://doi.org/10.1073/pnas.1305472110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23697367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23697367"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "J Tang, H Zhuo, X Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel biomarker Linc00974 interacting with KRT19 promotes proliferation and metastasis in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2014.518"}], "href": "https://doi.org/10.1038/cddis.2014.518"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25476897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25476897"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Dianne J Beveridge, Kirsty L Richardson, Michael R Epis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The tumor suppressor miR-642a-5p targets Wilms Tumor 1 gene and cell-cycle progression in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-97190-x"}], "href": "https://doi.org/10.1038/s41598-021-97190-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34504167"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34504167"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yuanlin Liu, Ye Wang, Xiang Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of lncRNA PCGEM1 inhibits cervical carcinoma by modulating the miR-642a-5p/LGMN axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Pathol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexmp.2020.104561"}], "href": "https://doi.org/10.1016/j.yexmp.2020.104561"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33121976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33121976"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xi Zhang, Rui Li "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA MAFG‑AS1 enhances radioresistance of glioblastoma cells via miR‑642a‑5p/Notch1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neurobiol Exp (Wars) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.55782/ane-2022-030"}], "href": "https://doi.org/10.55782/ane-2022-030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36214714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36214714"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jing Wang, Shaobin Xin, Rui Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of lncRNA LUCAT1 attenuates sepsis‑induced myocardial cell injury by sponging miR-642a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mamm Genome (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00335-021-09890-4"}], "href": "https://doi.org/10.1007/s00335-021-09890-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34272987"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34272987"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Liming Fei, Gengyun Sun, Qinghai You "}, {"type": "b", "children": [{"type": "t", "text": "miR-642a-5p partially mediates the effects of lipopolysaccharide on human pulmonary microvascular endothelial cells via eEF2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Open Bio (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/2211-5463.12969"}], "href": "https://doi.org/10.1002/2211-5463.12969"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32881411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32881411"}]}]}]}
Synonyms HSA-MIR-642A, HSA-MIR-642, MIR-642A, MIR642, MIRN642
NCBI Gene ID 693227
API
Download Associations
Predicted Functions View MIR642A's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR642A's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR642A's ARCHS4 Predicted Functions.

Functional Associations

MIR642A has 259 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.

Click the + buttons to view associations for MIR642A from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR642A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR642A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR642A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR642A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR642A gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR642A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR642A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR642A gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR642A from the GeneSigDB Published Gene Signatures dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR642A gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR642A gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR642A gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR642A gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR642A gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR642A gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.