MIR644A Gene

HGNC Family Non-coding RNAs
Name microRNA 644a
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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This action consequently modulated p53—shifting the balance between cell cycle arrest and apoptosis—and sensitized tumors to therapy, thereby highlighting its potential as a pleiotropic therapy-sensitizer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in gastric cancer, diminished miR-644a expression was associated with advanced clinical stage and metastasis; restoring its expression suppressed cell migration and invasion via CtBP1-mediated attenuation of EMT."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In hepatocellular carcinoma, lower levels of miR-644a were correlated with larger tumor size and higher TNM stage, while its enforced expression enhanced apoptosis by targeting heat shock factor 1 (HSF1) and activating a cascade of pro-apoptotic molecules."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these malignancies, miR-644a also plays a role in castration-resistant prostate cancer (CRPC) where its downregulation is linked to the dysregulation of multiple oncogenic pathways. In CRPC, miR-644a suppresses key drivers of tumorigenesis—including androgen receptor coregulators, c-Myc, antiapoptotic proteins (Bcl-xl/Bcl2), and several EMT promoters (ZEB1, CDK6, and Snail)—as well as elements supporting the Warburg effect, which collectively contribute to improved responses to anti-androgen therapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, in the context of environmental exposure, increased ambient PM2.5 levels are positively associated with miR-644a expression; this upregulation has been suggested to mediate deleterious effects on lung function, potentially linking miR-644a to the modulation of respiratory health in polluted environments."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kavleen Sikand, Jagjit Singh, Jey Sabith Ebron, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Housekeeping gene selection advisory: glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and β-actin are targets of miR-644a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0047510"}], "href": "https://doi.org/10.1371/journal.pone.0047510"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23091630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23091630"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Umar Raza, Özge Saatci, Stefan Uhlmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The miR-644a/CTBP1/p53 axis suppresses drug resistance by simultaneous inhibition of cell survival and epithelial-mesenchymal transition in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.10489"}], "href": "https://doi.org/10.18632/oncotarget.10489"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27409664"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27409664"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yingchao Li, Xiaoni Yan, Li Ren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-644a Inhibits Cellular Proliferation and Invasion via Suppression of CtBP1 in Gastric Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504016X14772410356982"}], "href": "https://doi.org/10.3727/096504016X14772410356982"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27983935"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27983935"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wenjin Liang, Yong Liao, Zeming Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-644a promotes apoptosis of hepatocellular carcinoma cells by downregulating the expression of heat shock factor 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Commun Signal (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12964-018-0244-z"}], "href": "https://doi.org/10.1186/s12964-018-0244-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29898735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29898735"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jey S Ebron, Eswar Shankar, Jagjit Singh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-644a Disrupts Oncogenic Transformation and Warburg Effect by Direct Modulation of Multiple Genes of Tumor-Promoting Pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-18-2993"}], "href": "https://doi.org/10.1158/0008-5472.CAN-18-2993"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30808676"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30808676"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiaowei Cong, Juan Zhang, Rongli Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Short-term ambient particulate air pollution exposure, microRNAs, blood pressure and lung function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Pollut (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.envpol.2021.118387"}], "href": "https://doi.org/10.1016/j.envpol.2021.118387"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34673158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34673158"}]}]}]}
Synonyms HSA-MIR-644A, HSA-MIR-644, MIRN644, MIR644
NCBI Gene ID 693229
API
Download Associations
Predicted Functions View MIR644A's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR644A's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR644A's ARCHS4 Predicted Functions.

Functional Associations

MIR644A has 193 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 13 datasets.

Click the + buttons to view associations for MIR644A from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR644A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR644A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR644A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR644A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR644A gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR644A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR644A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR644A gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR644A from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR644A gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of MIR644A gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR644A gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR644A gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.