MIR645 Gene

HGNC Family Non-coding RNAs
Name microRNA 645
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have examined the oncogenic role of miR‐645 across a spectrum of malignancies. In osteosarcoma, for example, miR‐645 has been implicated in the modulation of chemotherapeutic sensitivity; one study showed that in response to cisplatin treatment the long non‐coding RNA LINC00161 sequesters miR‐645, thereby relieving its inhibition on IFIT2 and promoting apoptosis, while a separate study found that elevated miR‐645 levels facilitate cell migration through direct targeting and suppression of the tumor suppressor NME2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma, aberrantly high miR‐645 expression is associated with aggressive clinical features; mechanistic studies indicate that miR‐645 promotes cell proliferation and colony formation and inhibits apoptosis by directly binding to the 3′‐UTR of SOX30, resulting in its downregulation and consequent impairment of p53 activation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in diffuse large B‐cell lymphoma, miR‐645 acts as an oncogenic driver by repressing DACH1 expression, thereby enhancing cell cycle progression and proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence also suggests a role for miR‐645 in other cancer types. Investigations in breast cancer have begun to explore its contribution to metastatic behavior"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", while studies in renal clear cell carcinoma indicate that miR‐645 may promote tumor growth and dissemination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In non–small cell lung cancer, research is underway to characterize the regulatory relationship between miR‐645 and TP53I11, further underscoring its potential role in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Collectively, these findings highlight miR‐645 as a multifaceted regulator of oncogenesis and a promising target for therapeutic intervention.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuan Wang, Li Zhang, Xifu Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00161 sensitises osteosarcoma cells to cisplatin-induced apoptosis by regulating the miR-645-IFIT2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2016.08.024"}], "href": "https://doi.org/10.1016/j.canlet.2016.08.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27609068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27609068"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Guang-Jun Jiao, Shi-Jun Zhang, Yi Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-645 promotes metastasis of osteosarcoma via targeting tumor suppressor NM23 nucleoside diphosphate kinase 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Pharmacol Physiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1440-1681.13006"}], "href": "https://doi.org/10.1111/1440-1681.13006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29956840"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29956840"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jie Tao, Zhikui Liu, Yufeng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-645 represses hepatocellular carcinoma progression by inhibiting SOX30-mediated p53 transcriptional activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Macromol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ijbiomac.2018.10.032"}], "href": "https://doi.org/10.1016/j.ijbiomac.2018.10.032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30312695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30312695"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ruihuan Wang, Jie Shen, Na Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-645 regulates the proliferation and apoptosis of diffuse large B-cell lymphoma by targeting DACH1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-020-00321-1"}], "href": "https://doi.org/10.1007/s13577-020-00321-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32529465"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32529465"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Y Cai, W-F Li, Y Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of microRNA-645 suppresses breast cancer cell metastasis via targeting DCDC2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2017)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29028086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29028086"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "J Chen, Y Shu, Q Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-645 promotes cell metastasis and proliferation of renal clear cell carcinoma by targeting GK5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2017)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29131260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29131260"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "B Zhu, T Tian, M Zhao "}, {"type": "b", "children": [{"type": "t", "text": "MiR-645 promotes proliferation and migration of non-small cell lung cancer cells by targeting TP53I11."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202006_21510"}], "href": "https://doi.org/10.26355/eurrev_202006_21510"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32572880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32572880"}]}]}]}
Synonyms HSA-MIR-645, MIRN645
NCBI Gene ID 693230
API
Download Associations
Predicted Functions View MIR645's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR645's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR645's ARCHS4 Predicted Functions.

Functional Associations

MIR645 has 294 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR645 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR645 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR645 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR645 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR645 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR645 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR645 from the GeneSigDB Published Gene Signatures dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR645 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR645 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR645 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR645 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR645 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.