{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn gastric cancer, miR‑647 has been shown to exert important regulatory effects on tumor progression. Several studies have demonstrated that reduced miR‑647 levels are associated with enhanced metastasis, and its restoration inhibits migration and invasion by directly targeting molecules such as SRF, thereby downregulating the SRF/MYH9 axis and other metastasis‐promoting genes (e.g., ANK2, FAK, and MMPs) and consequently suppressing tumor growth and dissemination."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In contrast, another investigation in gastric cancer reported that miR‑647 overexpression could promote cell proliferation, migration, and invasion via direct targeting of TP73, thereby suggesting an oncogenic role in this context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond gastric cancer, miR‑647 appears to have contrasting functions in other diseases. In colorectal cancer, its upregulation has been linked to enhanced cell proliferation and migration through the targeting of NFIX."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Similarly, in hepatocellular carcinoma, miR‑647 promotes proliferation, migration, and invasion by directly suppressing PTPRF and modulating downstream ERK signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, elevated miR‑647 expression in atherosclerosis samples"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "and its involvement in ovarian cancer via post‐transcriptional regulation—as illustrated by its sequestration by circ‑FAM53B leading to upregulation of oncogenic MDM2"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "—further highlight its diverse roles. In addition, preliminary data in glioma indicate that the function of miR‑647 remains to be clarified."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTaken together, these findings indicate that miR‑647 displays multifaceted, context‐dependent regulatory functions. Whether acting as a tumor suppressor or an oncogene, miR‑647 influences key cellular processes—including proliferation, migration, invasion, apoptosis, and chemoresistance—through its interactions with targets such as SRF, TP73, NFIX, and PTPRF. These contrasting roles underscore the importance of further investigation into the molecular mechanisms of miR‑647 to assess its potential as a therapeutic target in cancer and other diseases.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wenlong Cao, Weiyuan Wei, Zexu Zhan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of miR-647 in human gastric cancer suppression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2017.5383"}], "href": "https://doi.org/10.3892/or.2017.5383"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28098914"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28098914"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gengtai Ye, Kunzhai Huang, Jiang Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-647 Targets SRF-MYH9 Axis to Suppress Invasion and Metastasis of Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.20512"}], "href": "https://doi.org/10.7150/thno.20512"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28900514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28900514"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wenlong Cao, Weiyuan Wei, Zexu Zhan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of drug resistance and metastasis of gastric cancer cells via the microRNA647-ANK2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2018.3381"}], "href": "https://doi.org/10.3892/ijmm.2018.3381"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29328428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29328428"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiangqian Zhang, Min Zhang, Guifeng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor promoter role of miR‑647 in gastric cancer via repression of TP73."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9358"}], "href": "https://doi.org/10.3892/mmr.2018.9358"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30106095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30106095"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shaoqing Liu, Dingding Qu, Weiping Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR‑647 and miR‑1914 promote cancer progression equivalently by downregulating nuclear factor IX in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.7675"}], "href": "https://doi.org/10.3892/mmr.2017.7675"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28990086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28990086"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiangyang Ye, Rongxian Qiu, Xiongzhi He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-647 inhibits hepatocellular carcinoma cell progression by targeting protein tyrosine phosphatase receptor type F."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2017628"}], "href": "https://doi.org/10.1080/21655979.2021.2017628"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34969357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34969357"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "C-X Xu, L Xu, F-Z Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-647 promotes proliferation and migration of ox-LDL-treated vascular smooth muscle cells through regulating PTEN/PI3K/AKT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201908_18756"}], "href": "https://doi.org/10.26355/eurrev_201908_18756"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31486513"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31486513"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Dan Sun, Jianing Liu, Lili Zhou "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of circular RNA circ‑FAM53B predicts adverse prognosis and accelerates the progression of ovarian cancer via the miR‑646/VAMP2 and miR‑647/MDM2 signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2019.7366"}], "href": "https://doi.org/10.3892/or.2019.7366"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31638250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31638250"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Kun Qin, Ge Tian, Guangzhong Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-647 inhibits glioma cell proliferation, colony formation and invasion by regulating HOXA9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gene Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jgm.3153"}], "href": "https://doi.org/10.1002/jgm.3153"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31881106"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31881106"}]}]}]}