MIR649 Gene

HGNC Family Non-coding RNAs
Name microRNA 649
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA growing body of literature has investigated key regulators of genomic stability, cellular differentiation, and development. Several studies have focused on components of the cohesin complex—most notably SMC3—which is essential for sister chromatid cohesion, proper mitotic and meiotic segregation, and the execution of complex transcriptional programs governing hematopoiesis, oocyte integrity, and even cardiac morphogenesis. Disruptions in SMC3 function have been linked to developmental anomalies, tumor suppressor dysregulation, and aberrant chromatin architecture in diverse biological contexts, ranging from lymphoma and myeloid malignancies to congenital heart disease and pancreatic cancer. These investigations underscore the central role of cohesin and its accessory pathways in maintaining genome integrity and proper cellular function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast to these studies, miR-649 has been identified as a critical regulator within the viral replication framework. Specifically, research has demonstrated that miR-649 promotes herpes simplex virus type 1 (HSV-1) replication by directly targeting MALT1—a key mediator of the NF‑κB signaling pathway—without compromising host cell viability. Notably, miR-649 expression is downregulated following HSV-1 infection and is inversely correlated with MALT1 levels, suggesting that this microRNA plays a nuanced role in modulating antiviral signaling and may serve as a promising target for the development of novel antiviral therapies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alexander Kurze, Katharine A Michie, Sarah E Dixon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A positively charged channel within the Smc1/Smc3 hinge required for sister chromatid cohesion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2010.315"}], "href": "https://doi.org/10.1038/emboj.2010.315"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21139566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21139566"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tianjiao Wang, Brandi Glover, Gayla Hadwiger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Smc3 is required for mouse embryonic and adult hematopoiesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Hematol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.exphem.2018.11.008"}], "href": "https://doi.org/10.1016/j.exphem.2018.11.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30553776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30553776"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Judith Reichmann, Karen Dobie, Lisa M Lister, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tex19.1 inhibits the N-end rule pathway and maintains acetylated SMC3 cohesin and sister chromatid cohesion in oocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201702123"}], "href": "https://doi.org/10.1083/jcb.201702123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32232464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32232464"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Martín A Rivas, Cem Meydan, Christopher R Chin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41590-020-00827-8"}], "href": "https://doi.org/10.1038/s41590-020-00827-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33432228"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33432228"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Martin A Rivas, Ceyda Durmaz, Andreas Kloetgen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cohesin Core Complex Gene Dosage Contributes to Germinal Center Derived Lymphoma Phenotypes and Outcomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2021.688493"}], "href": "https://doi.org/10.3389/fimmu.2021.688493"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34621263"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34621263"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Wei-Ting Yueh, Vijay Pratap Singh, Jennifer L Gerton "}, {"type": "b", "children": [{"type": "t", "text": "Maternal Smc3 protects the integrity of the zygotic genome through DNA replication and mitosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.199800"}], "href": "https://doi.org/10.1242/dev.199800"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34935904"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34935904"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Zhanping Lu, Yinghua Wang, Anna L F V Assumpção, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Yin Yang 1 regulates cohesin complex protein SMC3 in mouse hematopoietic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Adv (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/bloodadvances.2023011411"}], "href": "https://doi.org/10.1182/bloodadvances.2023011411"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38531064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38531064"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Bowen Zhang, Yongchang Zhu, Zhen Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SMC3 contributes to heart development by regulating super-enhancer associated genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s12276-024-01293-0"}], "href": "https://doi.org/10.1038/s12276-024-01293-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39085358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39085358"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yi Zhang, Jun Dai, Jinfeng Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-649 promotes HSV-1 replication by directly targeting MALT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Virol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jmv.24728"}], "href": "https://doi.org/10.1002/jmv.24728"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27813118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27813118"}]}]}]}
Synonyms MIRN649, HSA-MIR-649
NCBI Gene ID 693234
API
Download Associations
Predicted Functions View MIR649's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR649's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR649's ARCHS4 Predicted Functions.

Functional Associations

MIR649 has 106 functional associations with biological entities spanning 3 categories (functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 4 datasets.

Click the + buttons to view associations for MIR649 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR649 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of MIR649 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR649 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR649 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.