{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSERTAD1, also known as Sei1 or TRIP‐Br1, acts as a multifaceted regulator of cell cycle and survival pathways in diverse biological contexts. In neurons, SERTAD1 is robustly induced by DNA damage, trophic factor deprivation, and beta‐amyloid, where it is required to initiate and propagate the apoptotic cell cycle that underlies developmental and pathological neuronal death. In pancreatic beta‐cells, its expression supports the assembly and activity of Cdk4–cyclin D complexes, thereby contributing to normal insulin secretion and glucose homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the developing heart, SERTAD1 functions as a transcriptional co‐activator by interacting with SMAD1 to enhance BMP signal–dependent gene expression, indicating its critical role in cardiogenesis. In addition, its oncogenic properties have been highlighted through its capacity to promote genomic instability; studies show that aberrant Sei1 expression induces the formation of double minute chromosomes, a hallmark of gene amplification observed in cancer, and that it modulates key components of DNA double‐strand break repair pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, SERTAD1—as TRIP-Br1—is implicated in the modulation of receptor stability in breast cancer where it differentially regulates the levels of the insulin receptor and insulin-like growth factor 1 receptor, thereby contributing to enhanced proliferative and survival signals. In addition, SERTAD1 functions as an adaptor protein during inflammasome activation by binding directly to NLRP3, diminishing its polyubiquitination by Cullin1, and consequently facilitating the production of key inflammatory mediators such as IL-1β and IL-18."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Pablo J Fernandez-Marcos, Cristina Pantoja, Agueda Gonzalez-Rodriguez, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Sertad1 plays an essential role in developmental and pathological neuron death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.6421-09.2010"}], "href": "https://doi.org/10.1523/JNEUROSCI.6421-09.2010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20237268"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20237268"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yin Peng, Shaomin Zhao, Langying Song, et al. 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