{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent work in pediatric high‐grade gliomas (pHGGs) has uncovered a notable role for miR-6500-3p, which, along with miR-137, is significantly downregulated in these aggressive tumors compared to pediatric low-grade gliomas (pLGGs). Restoration of miR-6500-3p in pHGG cell lines (SF188 and UW479) leads to a marked reduction in cell proliferation. This microRNA exerts its tumor-suppressive function by directly targeting key cell cycle regulators—CENPE, KIF14, and NCAPG—which are found at elevated levels in pHGGs. Furthermore, combining the knockdown of these targets with temozolomide treatment results in an enhanced suppression of tumor cell growth, underscoring the therapeutic potential of this mRNA/miRNA regulatory axis in pediatric glioma management."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Muh-Lii Liang, Tsung-Han Hsieh, Kim-Hai Ng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of miR-137 and miR-6500-3p promotes cell proliferation in pediatric high-grade gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7736"}], "href": "https://doi.org/10.18632/oncotarget.7736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26933822"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26933822"}]}]}]}