{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNumerous studies have established that interferon‐inducible guanylate‐binding proteins (GBPs) play central roles in host defense against intracellular pathogens by orchestrating processes such as oxidative burst, autophagy, inflammasome activation, and the regulation of cytokine and chemokine production. These GBP family members have been shown to target bacterial and parasitic vacuoles, facilitate the recruitment of antimicrobial effectors, and modulate cell‐intrinsic inflammatory responses in a range of infectious settings. In addition, specific genetic and biochemical analyses in various murine and human models demonstrate that GBPs not only contribute to the clearance of pathogens like Listeria, Mycobacteria, Toxoplasma gondii, and Chlamydia species but also regulate downstream signaling pathways—including MAP kinase and STAT1 activation—to preserve tissue integrity and modulate immune cell aging and metabolic fitness."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a distinct line of investigation into tumor biology, a study in gastric cancer has revealed that the circular RNA hsa_circ_0001368 acts as a competing endogenous RNA by sponging miR‐6506‐5p. This microRNA normally targets and suppresses the expression of FOXO3—a well‐recognized tumor‐suppressor gene—so that reduced levels of hsa_circ_0001368 lead to enhanced miR‐6506‐5p activity, diminished FOXO3 expression, and consequently, increased cell proliferation, invasion, and tumor progression. Thus, in this context, miR‐6506‐5p functions as a crucial negative regulator of FOXO3, and its modulation via ceRNA networks may offer promising avenues for therapeutic intervention in gastric cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Julie Mirpuri, Jennifer C Brazil, Andrew J Berardinelli, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0024434"}], "href": "https://doi.org/10.1371/journal.pone.0024434"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21931713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21931713"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Elizabeth M Selleck, Sarah J Fentress, Wandy L Beatty, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Infect Immun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/IAI.00856-15"}], "href": "https://doi.org/10.1128/IAI.00856-15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26416908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26416908"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiaoxue Qiu, Hong Guo, Junshu Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of guanylate binding protein 1 causes mitochondrial dysfunction and cellular senescence in macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-19828-7"}], "href": "https://doi.org/10.1038/s41598-018-19828-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29374208"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29374208"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yahya Sohrabi, Valeryia Volkova, Tatyana Kobets, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic Regulation of Guanylate-Binding Proteins 2b and 5 during Leishmaniasis in Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2018.00130"}], "href": "https://doi.org/10.3389/fimmu.2018.00130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29467757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29467757"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yinnan Meng, Wei Wang, Meng Chen, et al. 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