{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn gastric cancer, the long noncoding RNA HOXA10‐AS acts as an oncogene by modulating the HOXA10‐AS/miR-6509-5p/YBX1 signaling pathway. Elevated levels of HOXA10‐AS are associated with enhanced cell proliferation, migration, and invasion, in part by downregulating miR-6509-5p. This microRNA normally functions as a tumor suppressor, since its upregulation leads to impaired tumor cell growth and triggers apoptotic processes, suggesting that miR-6509-5p is a critical regulator of gastric cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nDisruption of the balance of this regulatory network, where suppression of miR-6509-5p by HOXA10‐AS relieves its inhibitory effect on YBX1, further supports the oncogenic potential of the lncRNA. The interaction between miR-6509-5p and YBX1 underscores a functional mechanism that can be crucial for both tumor growth and metastasis, highlighting miR-6509-5p as a potential biomarker and therapeutic target in the management of gastric cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shanshan Li, Chuanhui Lu, Xinyu Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA HOXA10-AS functions as an oncogene by binding miR-6509-5p to upregulate Y-box binding protein 1 in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2059615"}], "href": "https://doi.org/10.1080/21655979.2022.2059615"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35521747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35521747"}]}]}]}