{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough numerous studies have elucidated the roles of T‐box transcription factors—such as TBX6—in regulating mesoderm formation, somite segmentation, and fate specification during embryogenesis (e.g., PMIDs 21331042, 16505380, 12620991, 18579680, 17584735, 17668009, 18575602, 22546692, 12464437, 15986483, 30100166, 30307510, 18849530, 29084802, 19561075, 15864811, 31888956, 25641698, 23326414, 30548789, 20832395, 29895619, 29761784, 34256037, 31010673, 22721678, 32855167)—none of these developmental reports provide direct insights into the function of MIR6511B1. \n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, recent work in the field of colorectal cancer has implicated MIR6511B1, specifically its mature product miR‑6511b‑5p, in tumor progression. In DNA mismatch repair–proficient (pMMR) colorectal cancers, miR‑6511b‑5p is downregulated, suggesting that MIR6511B1 may normally act to restrain metastatic dissemination; its reduced expression could remove a critical inhibitory influence on distal metastasis. However, the precise molecular mechanisms by which MIR6511B1 might control metastasis in this context remain to be elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "JinMing Sun, Ling Ye, Yuan Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-6511b-5p suppresses metastasis of pMMR colorectal cancer through methylation of CD44 by directly targeting BRG1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12094-022-02845-4"}], "href": "https://doi.org/10.1007/s12094-022-02845-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35590122"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35590122"}]}]}]}