{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nColorectal cancer patients with distal metastases face a poor prognosis, and nearly 95% of metastatic cases exhibit DNA mismatch repair proficiency (pMMR). In this context, recent findings have shown that miR-6511b-5p—a form of MIR6511B2—is downregulated in pMMR colorectal cancer, hinting at its potential involvement in the regulatory networks that control metastatic progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThough the precise mechanism by which miR-6511b-5p influences metastasis remains unclear, its decreased expression in pMMR tumors suggests that MIR6511B2 could normally act to suppress pathways that promote tumor dissemination. Identifying the molecular targets and signaling cascades affected by miR-6511b-5p may provide valuable insights into novel therapeutic strategies for managing metastatic colorectal cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "JinMing Sun, Ling Ye, Yuan Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-6511b-5p suppresses metastasis of pMMR colorectal cancer through methylation of CD44 by directly targeting BRG1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12094-022-02845-4"}], "href": "https://doi.org/10.1007/s12094-022-02845-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35590122"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35590122"}]}]}]}