{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that dysregulation of MIR6515, including its isoforms miR-6515-3p and miR-6515-5p, plays significant roles in both cancer progression and inflammatory responses. These findings underscore the importance of this microRNA as a mediator linking epigenetic regulation to critical cellular pathways involved in disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn lung carcinoma models, miR-6515-3p appears to be under the epigenetic influence of the long noncoding RNA H19. Functional assays in lung cancer cell lines have demonstrated that inhibition of miR-6515-3p reduces cell proliferation and migration, suggesting that its aberrant expression may contribute to metastasis. These observations indicate that the H19/miR-6515-3p regulatory axis could be instrumental in lung cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn parallel, exposure of bronchial epithelial cells to particulate matter (PM10) has been shown to downregulate miR-6515-5p, thereby unleashing a cascade of pro-inflammatory effects. Overexpression of miR-6515-5p suppresses the production of key cytokines such as IL-6 and IL-8 by inactivating the MAPK/ERK signaling pathway, while its inhibition exacerbates inflammatory gene expression. The data further identify CSF3 as a direct target of miR-6515-5p, positioning this microRNA as a critical negative regulator of PM10-induced inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "YouZu Xu, Jian Lin, YingYing Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The miRNA hsa-miR-6515-3p potentially contributes to lncRNA H19-mediated-lung cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29006"}], "href": "https://doi.org/10.1002/jcb.29006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31131469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31131469"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Eun Suk Son, Ui Won Ko, Hee-Yeon Jeong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNA-6515-5p regulates particulate matter-induced inflammatory responses by targeting CSF3 in human bronchial epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Toxicol In Vitro (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tiv.2022.105428"}], "href": "https://doi.org/10.1016/j.tiv.2022.105428"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35798096"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35798096"}]}]}]}