MIR653 Gene

HGNC Family Non-coding RNAs
Name microRNA 653
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that miR‐653‐5p acts predominantly as a tumor‐suppressive microRNA by targeting various oncogenic transcripts and pathways. For instance, in neuroblastoma, the long noncoding RNA SNHG7 was shown to sponge miR‐653‐5p, leading to upregulated STAT2 expression and enhanced tumor progression, suggesting that miR‐653‐5p normally restrains proliferation, invasion, and epithelial–mesenchymal transition (EMT) via STAT2 inhibition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilar tumor‐suppressive roles for miR‐653‐5p have been documented in several other cancers. In renal cell carcinoma, the lncRNA PLK1S1 was found to suppress miR‐653 levels, resulting in increased expression of CXCR5 and contributing to tumorigenesis and drug resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In T‐cell acute lymphoblastic leukemia, circPRKDC sponges miR‐653‐5p, thereby releasing its target RELN and activating the PI3K/AKT/mTOR signaling pathway to promote cell proliferation while reducing apoptosis and autophagy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in breast cancer, overexpression of miR‐653‐5p inhibited cell proliferation, migration and EMT by directly targeting mitogen‐activated protein kinase 6 (MAPK6), reinforcing its tumor‐suppressive character."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies have extended these findings to other tumor types. In papillary thyroid carcinoma, exosomal circ007293 was shown to sponge miR‐653‐5p, leading to enhanced expression of PAX6 and facilitating EMT, invasion, and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Similarly, in non‐small cell lung cancer, circRANGAP1 was found to bind and diminish miR‐653‐5p levels, which in turn upregulated COL11A1 expression, thus promoting aggressive tumor features."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " A broader review additionally noted that while miR‐653‐5p generally functions as an inhibitor of tumor growth in cancers such as breast, renal, and lung, its role might differ and even be pro‐tumorigenic in other contexts, for example in bladder and prostate cancers, highlighting the complexity and context‐dependence of its regulatory network."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Renjie Chi, Xin Chen, Ming Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of SNHG7-miR-653-5p-STAT2 feedback loop in regulating neuroblastoma progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28017"}], "href": "https://doi.org/10.1002/jcp.28017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30623419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30623419"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Weiyuan Li, Dengke Yang, Yu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non‑coding RNA PLK1S1 was associated with renal cell carcinoma progression by interacting with microRNA‑653 and altering C‑X‑C chemokine receptor 5 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2020.7742"}], "href": "https://doi.org/10.3892/or.2020.7742"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33000253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33000253"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhang Ling, Zhi-Gang Fang, Jie-Yong Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The depletion of Circ-PRKDC enhances autophagy and apoptosis in T-cell acute lymphoblastic leukemia via microRNA-653-5p/Reelin mediation of the PI3K/AKT/mTOR signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kaohsiung J Med Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/kjm2.12352"}], "href": "https://doi.org/10.1002/kjm2.12352"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33615686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33615686"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mei Zhang, Hongwei Wang, Xiaomei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR‑653‑5p suppresses the growth and migration of breast cancer cells by targeting MAPK6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2021.11839"}], "href": "https://doi.org/10.3892/mmr.2021.11839"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33495824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33495824"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Qiuyu Lin, Qianle Qi, Sen Hou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal circular RNA hsa_circ_007293 promotes proliferation, migration, invasion, and epithelial-mesenchymal transition of papillary thyroid carcinoma cells through regulation of the microRNA-653-5p/paired box 6 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2000745"}], "href": "https://doi.org/10.1080/21655979.2021.2000745"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34866540"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34866540"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Min Chen, Jing Zhang, Jian Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular circRANGAP1 Contributes to Non-small Cell Lung Cancer Progression by Increasing COL11A1 Expression Through Sponging miR-653-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Genet (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10528-023-10393-x"}], "href": "https://doi.org/10.1007/s10528-023-10393-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37193942"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37193942"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Moussa Omorou, Yiwei Huang, Ning Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The emerging role of miR-653 in human cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Epidemiol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canep.2022.102208"}], "href": "https://doi.org/10.1016/j.canep.2022.102208"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35777307"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35777307"}]}]}]}
Synonyms MIR-653, HSA-MIR-653, MIRN653
NCBI Gene ID 724023
API
Download Associations
Predicted Functions View MIR653's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR653's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR653's ARCHS4 Predicted Functions.

Functional Associations

MIR653 has 206 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR653 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR653 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR653 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR653 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR653 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR653 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR653 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of MIR653 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR653 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR653 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR653 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR653 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR653 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.