MIR654 Gene

HGNC Family Non-coding RNAs
Name microRNA 654
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR‐654, in both its –3p and –5p forms, emerges as a context‐dependent regulator in human malignancies. In metastatic prostate cancer, miR‐654‑3p is markedly downregulated, with lower levels correlating with aggressive disease features."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In glioma, sequestration of miR‐654 by circHIPK3 leads to derepression of IGF2BP3, thereby promoting cell proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Conversely, in oral squamous cell carcinoma miR‐654‑5p acts in an oncogenic manner—its elevated expression enhances proliferation, metastasis, and chemoresistance via targeting GRAP and activating Ras/MAPK signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In several other cancer types, including ovarian serous carcinoma, papillary thyroid carcinoma, hepatocellular carcinoma, acute myeloid leukemia, non‑small‑cell lung cancer, esophageal squamous cell carcinoma and emerging studies in colorectal cancer, miR‑654 (predominantly the –3p/–5p species) generally displays tumor‐suppressive activities. These functions involve inhibition of cell proliferation and migration or induction of apoptosis through the downregulation of key oncogenic targets—such as CDCP1, PLAGL2"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", EMT drivers"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", and HDGF"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "—as well as by targeting RASAL2 in non‑small‑cell lung cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "and via similar ceRNA networks in esophageal carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " An investigation into its role in colorectal cancer has been initiated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOutside of classical oncogenesis, miR‑654 also modulates other pathological processes. In premature ovarian failure, suppression of miR‑654 by the lncRNA NEAT1 affects apoptosis and autophagy through the STC2/MAPK pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " In intervertebral disc degeneration, however, upregulation of miR‑654‑5p contributes to extracellular matrix degradation by inhibiting autophagy via direct targeting of ATG7."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In hepatocellular carcinoma, circRNA DOCK1 sponges miR‑654‑5p to upregulate SMAD2 expression, while similar competing endogenous RNA mechanisms are observed in laryngeal squamous cell carcinoma with circ_CORO1C regulating USP7 via miR‑654‑3p."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " In the context of cardiovascular pathology, miR‑654‑5p is downregulated in the plasma of patients with coronary artery disease and, when restored, its expression inhibits vascular smooth muscle cell proliferation and migration by targeting ADAMTS‑7."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Moreover, in colorectal cancer, circ_0084188 modulates the miR‑654‑3p/KLF12 axis, affecting tumor cell behaviors"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ", while additional studies in lung cancer further reinforce its tumor‑suppressive effects through interference with EMT, proliferation, and migration via modulation of RNF8 and SRC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": " Finally, in nasopharyngeal carcinoma, circEFR3A promotes tumor growth by sponging miR‑654‑3p which normally represses EFR3A, underscoring its role as an important regulatory switch."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "A Formosa, E K Markert, A M Lena, et al. 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Synonyms MIRN654, HSA-MIR-654, MIR-654
NCBI Gene ID 724024
API
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Predicted Functions View MIR654's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR654's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR654's ARCHS4 Predicted Functions.

Functional Associations

MIR654 has 273 functional associations with biological entities spanning 5 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR654 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR654 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR654 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
CTD Gene-Disease Associations diseases associated with MIR654 gene/protein from the curated CTD Gene-Disease Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR654 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR654 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR654 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR654 from the GeneSigDB Published Gene Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR654 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR654 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR654 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR654 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.