MIR657 Gene

HGNC Family Non-coding RNAs
Name microRNA 657
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have identified miR-657 as an important regulator in hepatocellular carcinoma and type 2 diabetes. In hepatocellular carcinoma, miR-657 expression is induced by hepatitis viral proteins and is up-regulated in tumor tissues, where it promotes cell proliferation, colony formation, and tumor development in vivo by directly targeting the 3′UTR of TLE1 and activating the NF-κB signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Complementarily, in type 2 diabetes, bioinformatic predictions and luciferase assays have demonstrated that miR-657 directly binds the 3′UTR of IGF2R. A common ACAA-insertion/deletion polymorphism within this binding site modulates miR-657–mediated repression of IGF2R expression, suggesting a mechanism through which altered IGF2R levels contribute to disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer diagnosis and inflammatory disorders, miR-657 also emerges as a robust biomarker and functional mediator. Elevated miR-657 levels in early larynx carcinoma, when combined with down-regulated miR-1287, yield a highly sensitive and specific classifier for early detection of the disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Likewise, in gestational diabetes mellitus, increased miR-657 negatively correlates with IL-37 expression. By targeting IL-37, miR-657 enhances macrophage proliferation and inflammatory cytokine production via the NF-κB pathway, implicating its dysregulation in the underlying inflammatory processes of the disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, miR-657 plays a critical role in retinoblastoma by promoting tumor progression. Elevated miR-657 expression is associated with markedly reduced levels of PPARA, a key regulatory factor in cell growth. Functional assays indicate that miR-657 directly inhibits PPARA expression, thereby enhancing cell proliferation, migration, and tumorigenesis in retinoblastoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lisheng Zhang, Lixin Yang, Xiyong Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-657 promotes tumorigenesis in hepatocellular carcinoma by targeting transducin-like enhancer protein 1 through nuclear factor kappa B pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.26162"}], "href": "https://doi.org/10.1002/hep.26162"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23175432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23175432"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ke Lv, Yingjun Guo, Yiliang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Allele-specific targeting of hsa-miR-657 to human IGF2R creates a potential mechanism underlying the association of ACAA-insertion/deletion polymorphism with type 2 diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2008.06.102"}], "href": "https://doi.org/10.1016/j.bbrc.2008.06.102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18602895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18602895"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yan Wang, Mingtao Chen, Zezhang Tao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of predictive biomarkers for early diagnosis of larynx carcinoma based on microRNA expression data."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cancergen.2013.09.005"}], "href": "https://doi.org/10.1016/j.cancergen.2013.09.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24238754"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24238754"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Pingping Wang, Haidong Wang, Cuihong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dysregulation of microRNA-657 influences inflammatory response via targeting interleukin-37 in gestational diabetes mellitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.27468"}], "href": "https://doi.org/10.1002/jcp.27468"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30362558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30362558"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiumei He, Yueyue Feng "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA hsa-miR-657 promotes retinoblastoma malignancy by inhibiting peroxisome proliferator-activated receptor alpha expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Drugs (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CAD.0000000000001308"}], "href": "https://doi.org/10.1097/CAD.0000000000001308"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35324527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35324527"}]}]}]}
Synonyms HSA-MIR-657, MIRN657
NCBI Gene ID 724027
API
Download Associations
Predicted Functions View MIR657's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR657's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR657's ARCHS4 Predicted Functions.

Functional Associations

MIR657 has 271 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.

Click the + buttons to view associations for MIR657 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR657 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR657 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR657 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR657 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR657 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR657 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR657 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR657 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR657 from the GeneSigDB Published Gene Signatures dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR657 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR657 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR657 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR657 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR657 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.