MIR662 Gene

HGNC Family Non-coding RNAs
Name microRNA 662
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have provided important insights into the complex regulatory networks that control both organelle biogenesis and cellular stress responses. For example, several investigations have elucidated the role of WDR35 in cilia formation, intracellular trafficking, and stress‐induced signaling events. Mutations in WDR35 underlie severe skeletal ciliopathies, and its expression is tightly controlled by ROS‐dependent signaling pathways involving CaMKK/AMPK/p38 MAPK and NF‑κB activation. Moreover, structural and functional analyses indicate that WDR35 is a key component of protein complexes necessary for ciliary trafficking, highlighting an intricate interplay between vesicular transport and signaling regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast to these protein‐centric studies, emerging evidence from cancer research has highlighted a significant role for microRNAs in modulating oncogenic processes. In particular, overexpression of miR‑662, along with miR‑192 and miR‑192*, has been shown to correlate with poor prognosis in early‑stage squamous cell lung cancer and has been implicated in the development of chemoresistance, suggesting that miR‑662 functions as an oncogenic regulator. Similarly, investigations into breast cancer metastasis further support a role for deregulated microRNA networks—including miR‑662—in facilitating metastatic dissemination, although the precise molecular mechanisms remain to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Pleasantine Mill, Paul J Lockhart, Elizabeth Fitzpatrick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2011.03.015"}], "href": "https://doi.org/10.1016/j.ajhg.2011.03.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21473986"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21473986"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lei Huang, Fumio Kondo, Misako Harato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced expression of WD repeat-containing protein 35 via nuclear factor-kappa B activation in bupivacaine-treated Neuro2a cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0086336"}], "href": "https://doi.org/10.1371/journal.pone.0086336"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24466034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24466034"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lei Huang, Fumio Kondo, Masahiko Gosho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced expression of WD repeat-containing protein 35 via CaMKK/AMPK activation in bupivacaine-treated Neuro2a cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0098185"}], "href": "https://doi.org/10.1371/journal.pone.0098185"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24859235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24859235"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tooba Quidwai, Jiaolong Wang, Emma A Hall, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A WDR35-dependent coat protein complex transports ciliary membrane cargo vesicles to cilia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.69786"}], "href": "https://doi.org/10.7554/eLife.69786"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34734804"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34734804"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Martyna Filipska, Marcin Skrzypski, Katarzyna Czetyrbok, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-192 and miR-662 enhance chemoresistance and invasiveness of squamous cell lung carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lung Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lungcan.2018.02.002"}], "href": "https://doi.org/10.1016/j.lungcan.2018.02.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29571988"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29571988"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Margherita Puppo, Manoj Kumar Valluru, Martine Croset, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-662 is associated with metastatic relapse in early-stage breast cancer and promotes metastasis by stimulating cancer cell stemness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41416-023-02340-9"}], "href": "https://doi.org/10.1038/s41416-023-02340-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37443350"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37443350"}]}]}]}
Synonyms MIRN662, HSA-MIR-662
NCBI Gene ID 724032
API
Download Associations
Predicted Functions View MIR662's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR662's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR662's ARCHS4 Predicted Functions.

Functional Associations

MIR662 has 230 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR662 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR662 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR662 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR662 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR662 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR662 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR662 from the GeneSigDB Published Gene Signatures dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with MIR662 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR662 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR662 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR662 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR662 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.