MIR663B Gene

HGNC Family Non-coding RNAs
Name microRNA 663b
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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In gastric cancer, MIR663B is frequently transcriptionally silenced by DNA hypermethylation, and its restoration suppresses cell growth, migration, invasion, and epithelial–mesenchymal transition (EMT), underscoring its tumor‑suppressive properties."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in pancreatic cancer, epigenetic downregulation of MIR663B leads to enhanced proliferation, invasion, and reduced apoptosis via derepression of insulin‑like growth factor‑2 (IGF2), while overexpression of MIR663B counteracts these malignant traits."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In contrast, in breast cancer, MIR663B is upregulated in tamoxifen‑resistant cells where it directly targets TP73, promoting resistance by diminishing drug sensitivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In hepatocellular carcinoma, MIR663B is expressed at low levels and its upregulation suppresses both proliferation and invasion by targeting the oncogenic adaptor protein GAB2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In bladder cancer, elevated MIR663B not only targets the tumor suppressor TUSC2 to enhance cell viability and inhibit apoptosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", but exosomal MIR663B derived from cancer cells further promotes proliferation and EMT."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Moreover, in cervical cancer cells, TGF‑β1 stimulates the secretion of exosomes enriched in MIR663B that subsequently downregulate the glycosyltransferase MGAT3, thereby accelerating the EMT process and enhancing metastatic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOutside of oncogenesis, MIR663B also contributes to the regulation of inflammatory responses. In pulmonary hypertension, exosomal MIR663B derived from M1 macrophages has been shown to induce dysfunction in pulmonary artery smooth muscle cells, suggesting a role in vascular remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Additionally, in intervertebral disc degeneration, overexpression of MIR663B in nucleus pulposus cells targets the interleukin‑1 receptor (IL1R1), thereby inhibiting the production of inflammatory mediators, reducing cellular apoptosis, and preserving extracellular matrix components."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Liu Peng, Qiu Chun-guang, Li Bei-fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical impact of circulating miR-133, miR-1291 and miR-663b in plasma of patients with acute myocardial infarction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diagn Pathol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1746-1596-9-89"}], "href": "https://doi.org/10.1186/1746-1596-9-89"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24885383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24885383"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Loris De Cecco, Matteo Capaia, Simona Zupo, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Epigenetically silenced microRNAs in gastric cancer: Functional analysis and identification of their target genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.4036"}], "href": "https://doi.org/10.3892/or.2015.4036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26043902"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26043902"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Huihua Cai, Yong An, Xuemin Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic inhibition of miR-663b by long non-coding RNA HOTAIR promotes pancreatic cancer cell proliferation via up-regulation of insulin-like growth factor 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.13490"}], "href": "https://doi.org/10.18632/oncotarget.13490"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27895308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27895308"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hua Jiang, Lin Cheng, Pan Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑663b mediates TAM resistance in breast cancer by modulating TP73 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9064"}], "href": "https://doi.org/10.3892/mmr.2018.9064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29845295"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29845295"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Liping Guo, Baoli Li, Meijing Miao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑663b targets GAB2 to restrict cell proliferation and invasion in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.9934"}], "href": "https://doi.org/10.3892/mmr.2019.9934"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30720118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30720118"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jianying Chen, Bo Song, Guangqi Kong "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑663b downregulation inhibits proliferation and induces apoptosis in bladder cancer cells by targeting TUSC2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.10023"}], "href": "https://doi.org/10.3892/mmr.2019.10023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30896880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30896880"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xinbao Yin, Xueping Zheng, Ming Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal miR-663b targets Ets2-repressor factor to promote proliferation and the epithelial-mesenchymal transition of bladder cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbin.11292"}], "href": "https://doi.org/10.1002/cbin.11292"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31872468"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31872468"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xuewu You, Ying Wang, Jinyu Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal miR‑663b exposed to TGF‑β1 promotes cervical cancer metastasis and epithelial‑mesenchymal transition by targeting MGAT3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2021.7963"}], "href": "https://doi.org/10.3892/or.2021.7963"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33649791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33649791"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Honghong Ma, Yang Yu, Lirong Mo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal miR-663b from \"M1\" macrophages promotes pulmonary artery vascular smooth muscle cell dysfunction through inhibiting the AMPK/Sirt1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.204690"}], "href": "https://doi.org/10.18632/aging.204690"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37142272"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37142272"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Y-X Li, X-X Ma, C-L Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The effect of microRNA-663b in the inhibition of interleukin-1-induced nucleus pulposus cell apoptosis and inflammatory response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol Pharmacol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26402/jpp.2023.1.09"}], "href": "https://doi.org/10.26402/jpp.2023.1.09"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37245236"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37245236"}]}]}]}
Synonyms MIR-663B, MIRN663B
NCBI Gene ID 100313824
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Download Associations
Predicted Functions View MIR663B's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR663B's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR663B's ARCHS4 Predicted Functions.

Functional Associations

MIR663B has 1,195 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 13 datasets.

Click the + buttons to view associations for MIR663B from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR663B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR663B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR663B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR663B gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR663B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR663B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR663B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR663B gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR663B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR663B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR663B gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of MIR663B gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR663B gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.