MIR670 Gene

HGNC Family Non-coding RNAs
Name microRNA 670
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn glioblastoma, elevated levels of miR‑670‑3p contribute to tumor progression by suppressing ferroptosis through direct targeting of ACSL4. This suppression limits ferroptosis‐induced cell death, thereby promoting cell growth and compromising the tumor’s sensitivity to chemotherapeutic agents such as temozolomide. Consequently, inhibition of miR‑670‑3p triggers ferroptosis and significantly impairs glioblastoma cell proliferation, indicating its potential as a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn non‑small cell lung cancer (NSCLC), the oncogenic effects of miR‑670‑5p are modulated by circular RNAs such as circsSMARCA5. Here, downregulation of circsSMARCA5 leads to an aberrant increase in miR‑670‑5p levels, which in turn suppresses the expression of the tumor suppressor RBM24. This regulatory axis suggests that the imbalance of miR‑670‑5p activity, mediated via its interaction with competitive endogenous RNAs, plays a critical role in enhancing NSCLC tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, in lung cancer, miR‑670‑5p is overexpressed and functions as an oncogene by targeting and downregulating the tumor suppressor gene WWOX. This targeting results in increased cell proliferation, migration, and invasion, while its inhibition leads to elevated levels of cell cycle regulator P21 and adhesion molecule E‑cadherin, along with reduced expression of MMP‑2. Such findings underscore the pivotal role of miR‑670‑5p in driving malignancy and highlight its potential as a molecular target for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chong Bao, Jing Zhang, Shu-Yue Xian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-670-3p suppresses ferroptosis of human glioblastoma cells through targeting ACSL4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/10715762.2021.1962009"}], "href": "https://doi.org/10.1080/10715762.2021.1962009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34323631"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34323631"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Danjie Zhang, Yuefeng Ma, Zhenchuan Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA SMARCA5 suppressed non-small cell lung cancer progression by regulating miR-670-5p/RBM24 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmaa099"}], "href": "https://doi.org/10.1093/abbs/gmaa099"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33085761"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33085761"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hong-Xia Li, Fang Liu, Jun-Hua Xia "}, {"type": "b", "children": [{"type": "t", "text": "[Effects of miR-670-5p on proliferation, migration and invasion of lung cancer cells]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhongguo Ying Yong Sheng Li Xue Za Zhi (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12047/j.cjap.6102.2021.046"}], "href": "https://doi.org/10.12047/j.cjap.6102.2021.046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34816661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34816661"}]}]}]}
Synonyms HSA-MIR-670
NCBI Gene ID 100313777
API
Download Associations
Predicted Functions View MIR670's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR670's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR670's ARCHS4 Predicted Functions.

Functional Associations

MIR670 has 368 functional associations with biological entities spanning 4 categories (molecular profile, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 13 datasets.

Click the + buttons to view associations for MIR670 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR670 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR670 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR670 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR670 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR670 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR670 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR670 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR670 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of MIR670 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR670 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR670 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR670 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR670 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.