{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR6715B appears to be a candidate noncoding RNA implicated in the genetic etiology of diseases such as primary ovarian insufficiency (POI). In studies focused on POI (1), its genomic region was highlighted in efforts to uncover the largely unknown genetic basis of this female infertility disorder, suggesting that MIR6715B may be involved in ovarian development or function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "MIR6715B is also discussed in the context of RNA transcription regulation. In gene expression analyses investigating the diurnal regulation of RNA polymerase III (Pol III)‐dependent transcription (2), the interplay between nutrient signals and circadian clock mechanisms was shown to govern the transcriptional output of small noncoding RNAs. Although MIR6715B is a microRNA, its potential regulatory roles may intersect with the dynamic modulation of transcription as cells anticipate and respond to metabolic cues, placing it among transcripts whose accumulation is finely tuned by both feeding and internal circadian signals."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "Furthermore, investigations into liver regeneration after partial hepatectomy (3) have revealed that Pol III transcription adapts to increased cellular proliferation by modulating the occupancy of target genes, including those encoding various noncoding RNAs. In this regenerative setting, MIR6715B may represent one of the responsive noncoding elements that integrates transcriptional adaptations to meet the heightened demands of cellular growth and division."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Monica M Franca, Xingfa Han, Mariana F A Funari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exome Sequencing Reveals the POLR3H Gene as a Novel Cause of Primary Ovarian Insufficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2018-02485"}], "href": "https://doi.org/10.1210/jc.2018-02485"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30830215"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30830215"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "François Mange, Viviane Praz, Eugenia Migliavacca, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diurnal regulation of RNA polymerase III transcription is under the control of both the feeding-fasting response and the circadian clock."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gr.217521.116"}], "href": "https://doi.org/10.1101/gr.217521.116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28341772"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28341772"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Meghdad Yeganeh, Viviane Praz, Cristian Carmeli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential regulation of RNA polymerase III genes during liver regeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gky1282"}], "href": "https://doi.org/10.1093/nar/gky1282"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30597109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30597109"}]}]}]}