{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn diabetic retinopathy, miR‑6720‑5p plays a pivotal regulatory role in the retinal microvasculature where its expression is inversely associated with that of the long non‑coding RNA MEG3 and its downstream effector, cytochrome B5 reductase 2 (CYB5R2). Under high‑glucose conditions, MEG3 and CYB5R2 are upregulated while miR‑6720‑5p is downregulated, and functional assays revealed that reduction of MEG3 or CYB5R2 promotes endothelial proliferation, migration, and tube formation. Notably, intervening with miR‑6720‑5p was able to reverse the pro‑angiogenic effects induced by MEG3 knockdown, an outcome that was negated by silencing CYB5R2—underscoring that miR‑6720‑5p’s regulation of CYB5R2 is critical in modulating neovascularization in diabetic retinopathy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nIn gastric cancer, miR‑6720‑5p is similarly integral to a regulatory axis controlling cell proliferation and apoptosis. Here, the long non‑coding RNA ACTA2‑AS1 functions as a molecular sponge for miR‑6720‑5p, thereby relieving miR‑6720‑5p‑mediated suppression of its target gene ESRRB. The resultant upregulation of ESRRB contributes to the inhibition of gastric cancer cell proliferation and the induction of apoptosis, highlighting a tumor‑suppressive mechanism driven by the ACTA2‑AS1–miR‑6720‑5p–ESRRB axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jinpeng Chen, Lin Liao, Huiyong Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA MEG3 inhibits neovascularization in diabetic retinopathy by regulating microRNA miR-6720-5p and cytochrome B5 reductase 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2000721"}], "href": "https://doi.org/10.1080/21655979.2021.2000721"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34978518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34978518"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zuchao Hu, Zhen Chen, Wei Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA ACTA2-AS1 Inhibits Cell Growth and Facilitates Apoptosis in Gastric Cancer by Binding with miR-6720-5p to Regulate ESRRB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Genet (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10528-023-10399-5"}], "href": "https://doi.org/10.1007/s10528-023-10399-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37222961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37222961"}]}]}]}