{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn cervical cancer, miR‑6727‑5p has been identified as a key regulator of tumor suppressive pathways through its direct interaction with the T‑box transcription factor TBX1. Under normal circumstances, TBX1 function inhibits cell proliferation, migration, and invasion while enhancing apoptosis and chemosensitivity; however, binding of miR‑6727‑5p to TBX1 leads to its downregulation, thereby promoting oncogenic signaling via the AKT and MAPK pathways. These findings not only emphasize the role of miR‑6727‑5p in modulating TBX1 expression and function but also suggest its potential contribution to cervical cancer progression and therapy resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nIn high‑grade serous ovarian carcinoma, circulating miR‑6727‑5p has been implicated as a prognostic biomarker, with higher serum levels correlating with poorer progression‑free outcomes. As part of a broader serum miRNA profile analysis, elevated miR‑6727‑5p expression was found to be significantly associated with adverse progression-free survival, thereby underscoring its potential utility in noninvasive prognostic evaluations for this aggressive cancer subtype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Haixia Liu, Mei Song, Xiaoyan Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "T-box transcription factor TBX1, targeted by microRNA-6727-5p, inhibits cell growth and enhances cisplatin chemosensitivity of cervical cancer cells through AKT and MAPK pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1880732"}], "href": "https://doi.org/10.1080/21655979.2021.1880732"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33557670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33557670"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kosuke Yoshida, Akira Yokoi, Juntaro Matsuzaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular microRNA profiling for prognostic prediction in patients with high-grade serous ovarian carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.15154"}], "href": "https://doi.org/10.1111/cas.15154"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34618992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34618992"}]}]}]}