| HGNC Family | Non-coding RNAs |
| Name | microRNA 6730 |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn papillary thyroid cancer, MIR6730 appears among a set of dysregulated miRNAs that distinguish tumor from non‐tumor tissue. Specifically, its altered expression contributes to a four‐miRNA prognostic signature that can reliably stratify patients into high‐risk and low‐risk groups based on overall survival outcomes. Although the exact molecular mechanisms of MIR6730 remain to be fully defined, its differential regulation in cancer versus normal tissues suggests it may participate in tumorigenic pathways—potentially acting in an oncogenic or tumor‐suppressive manner—and thus holds promise as a clinically useful biomarker for prognostication in PTC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiong Chengfeng, Cai Gengming, Zhang Junjia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA signature predicts survival in papillary thyroid carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28966"}], "href": "https://doi.org/10.1002/jcb.28966"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31099134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31099134"}]}]}]}
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| Synonyms | HSA-MIR-6730 |
| NCBI Gene ID | 102466722 |
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| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MIR6730 has 0 functional associations with biological entities spanning 0 categories () extracted from 0 datasets.
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If available, associations are ranked by standardized value
| Dataset | Summary |
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