{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn breast cancer, chemoresistance remains a significant clinical challenge, often linked to the deregulation of noncoding RNAs. One study reported that the long noncoding RNA RP11‑70C1.3 is upregulated in chemoresistant breast cancer cells and is associated with poorer patient prognosis. Mechanistic investigations revealed that RP11‑70C1.3 acts as a competing endogenous RNA (ceRNA) by sponging miR‑6736‑3p, thereby relieving its inhibitory effect on neuropilin‑1 (NRP‑1) expression. Downregulation of RP11‑70C1.3 reduced multidrug resistance in both in vitro and in vivo models, whereas rescue experiments with miR‑6736‑3p inhibitors or NRP‑1 overexpression could partially reverse this effect. These findings underscore the critical role of miR‑6736‑3p in the RP11‑70C1.3-mediated regulation of NRP‑1, suggesting that therapeutic targeting of this RNA network may enhance the efficacy of chemotherapy in breast cancer patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lansheng Zhang, Xia Zheng, Anqi Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA RP11-70C1.3 confers chemoresistance of breast cancer cells through miR-6736-3p/NRP-1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bosn J Basic Med Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.17305/bjbms.2021.5803"}], "href": "https://doi.org/10.17305/bjbms.2021.5803"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34374639"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34374639"}]}]}]}