{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that miR-6745 plays a critical tumor‐suppressing role in gastric cancer by targeting tissue inhibitor matrix metalloproteinase 1 (TIMP1), a protein previously implicated as an oncogene in colon cancer. Notably, gastric cancer tissues exhibit increased TIMP1 expression compared with normal gastric tissues, setting the stage for understanding the miR-6745–TIMP1 regulatory axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic investigations have demonstrated that miR-6745 directly binds to TIMP1, leading to its downregulation. This interaction mimics the effects observed when TIMP1 is experimentally silenced in gastric cancer cells. As a consequence, the suppression of TIMP1 by miR-6745 results in the inhibition of the Wnt/β-catenin signaling pathway, which is critical for cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, analysis of gastric cancer tissue samples revealed a significant inverse correlation between miR-6745 and TIMP1 expression, reinforcing the notion that disruption of the miR-6745–TIMP1 axis contributes to gastric tumorigenesis. These findings not only underscore the importance of this molecular pathway in disease progression but also highlight its potential as a therapeutic target for preventing or treating gastric cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hui Liu, Yuan Xiang, Qi-Bei Zong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-6745-TIMP1 axis inhibits cell growth and metastasis in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.203688"}], "href": "https://doi.org/10.18632/aging.203688"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34775375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34775375"}]}]}]}