{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nCyclin D3 functions as a pivotal regulator of cell cycle progression by forming active complexes with CDK4/6 and ensuring proper G1‐to‐S phase transition in a variety of cell types. In lymphoid lineages, cyclin D3 is essential for the expansion of immature T cells and pre–B cells, where its regulated expression and timely degradation—mediated by specific kinases such as DYRK1A—help couple proliferation with cellular differentiation and immunoglobulin recombination. Dysregulation of cyclin D3 contributes to lymphoid malignancies and perturbs allelic exclusion of antigen receptor genes, thereby amplifying transformation risk."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical cell cycle role in hematopoietic cells, cyclin D3 exerts important functions in nonhematopoietic tissues. In the uterus, cyclin D3 is critical for proper stromal cell decidualization—a process that involves both proliferation and subsequent polyploid differentiation—where its expression is modulated by hormonal and cytokine signals. In adipocytes, cyclin D3 acts in a cell cycle–independent manner by interacting with nuclear receptors to coactivate transcription and drive adipogenesis, while in the liver and muscle, distinct regulatory pathways govern its modest induction or stabilization, ensuring that proliferative cues are finely balanced with differentiation and metabolic programming."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, cyclin D3 participates in broader transcriptional and signaling networks that coordinate cellular responses to external stimuli. It contributes to the formation and expansion of germinal center B cells by modulating dark zone proliferation in response to T cell–dependent signals and interleukin‐21, and its aberrant levels can affect cellular transformation in fibroblasts and other lineages. Additional studies describe how cyclin D3 complexes with partner kinases control not only cell cycle progression but also the repression or activation of lineage‐specific gene programs, thereby influencing outcomes from skeletal muscle differentiation and regeneration to erythroid precursor divisions and cell fate decisions in B cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "31"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these studies underscore that cyclin D3 has multifaceted roles extending well beyond a simple cell cycle mediator—it integrates extracellular cues with intracellular responses to regulate proliferation, differentiation, and even genomic stability in a tissue‐ and context–dependent manner. Although the specific microRNA MIR6746 was not directly addressed in these reports, the extensive body of work on cyclin D3 suggests that any modulation by MIR6746 in similar systems could influence these critical processes. Future investigations into such microRNA–mediated regulation may further unravel how cyclin D3’s expression and activity are fine‐tuned in both normal physiology and disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "N Tiefenbrun, D Melamed, N Levy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (1996)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.16.7.3934"}], "href": "https://doi.org/10.1128/MCB.16.7.3934"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "8668211"}], "href": "https://pubmed.ncbi.nlm.nih.gov/8668211"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ewa Sicinska, Iannis Aifantis, Laurent Le Cam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requirement for cyclin D3 in lymphocyte development and T cell leukemias."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1535-6108(03)00301-5"}], "href": "https://doi.org/10.1016/s1535-6108(03"}, {"type": "t", "text": "00301-5) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14706337"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14706337"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Malay Mandal, Sarah E Powers, Kyoko Ochiai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.1785"}], "href": "https://doi.org/10.1038/ni.1785"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19734904"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19734904"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Benjamin J Thompson, Rahul Bhansali, Lauren Diebold, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20150002"}], "href": "https://doi.org/10.1084/jem.20150002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26008897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26008897"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Erica J Culberson, Kymberle C Shields, Rebecca A Glynn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Cyclin D3 Protein Enforces Monogenic TCRβ Expression by Mediating TCRβ Protein-Signaled Feedback Inhibition of Vβ Recombination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.2300623"}], "href": "https://doi.org/10.4049/jimmunol.2300623"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38117277"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38117277"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jian Tan, Shefali Raja, Marilyn K Davis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence for coordinated interaction of cyclin D3 with p21 and cdk6 in directing the development of uterine stromal cell decidualization and polyploidy during implantation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mech Dev (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0925-4773(01)00614-1"}], "href": "https://doi.org/10.1016/s0925-4773(01"}, {"type": "t", "text": "00614-1) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11804782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11804782"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "David G Rickheim, Christopher J Nelsen, John T Fassett, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential regulation of cyclins D1 and D3 in hepatocyte proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/jhep.2002.33996"}], "href": "https://doi.org/10.1053/jhep.2002.33996"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12085346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12085346"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Takaaki Matsui, Taisei Kinoshita, Toshio Hirano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STAT3 down-regulates the expression of cyclin D during liver development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M203184200"}], "href": "https://doi.org/10.1074/jbc.M203184200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12147685"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12147685"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "David A Sarruf, Irena Iankova, Anna Abella, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.22.9985-9995.2005"}], "href": "https://doi.org/10.1128/MCB.25.22.9985-9995.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16260612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16260612"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Parham Ramezani-Rad, Cindi Chen, Zilu Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2020.108403"}], "href": "https://doi.org/10.1016/j.celrep.2020.108403"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33207194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33207194"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jean-Bernard Lazaro, Peter J Bailey, Andrew B Lassar "}, {"type": "b", "children": [{"type": "t", "text": "Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.U-9988R"}], "href": "https://doi.org/10.1101/gad.U-9988R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12130539"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12130539"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Qiuhong Chen, Jie Lin, Shigeki Jinno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of Cdk6-cyclin D3 highly sensitizes cells to physical and chemical transformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1206193"}], "href": "https://doi.org/10.1038/sj.onc.1206193"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12592386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12592386"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Hyeon-Woo Lee, Kyung-Ok Nam, Su-Jung Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "4-1BB enhances CD8+ T cell expansion by regulating cell cycle progression through changes in expression of cyclins D and E and cyclin-dependent kinase inhibitor p27kip1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.200323996"}], "href": "https://doi.org/10.1002/eji.200323996"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12884287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12884287"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Renate Faast, Josephine White, Peter Cartwright, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cdk6-cyclin D3 activity in murine ES cells is resistant to inhibition by p16(INK4a)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1207133"}], "href": "https://doi.org/10.1038/sj.onc.1207133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14724578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14724578"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Florence Bernardin-Fried, Tanawan Kummalue, Suzanne Leijen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M310023200"}], "href": "https://doi.org/10.1074/jbc.M310023200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14747476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14747476"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Guo-Li Wang, Xiurong Shi, Elizabeth Salisbury, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclin D3 maintains growth-inhibitory activity of C/EBPalpha by stabilizing C/EBPalpha-cdk2 and C/EBPalpha-Brm complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.26.7.2570-2582.2006"}], "href": "https://doi.org/10.1128/MCB.26.7.2570-2582.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16537903"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16537903"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jennifer M Mataraza, Joseph R Tumang, Maria R Gumina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of cyclin D3 blocks proliferation of normal B-1a cells, but loss of cyclin D3 is compensated by cyclin D2 in cyclin D3-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.177.2.787"}], "href": "https://doi.org/10.4049/jimmunol.177.2.787"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16818732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16818732"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Ewa Sicinska, Young-Mi Lee, Judith Gits, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00800-06"}], "href": "https://doi.org/10.1128/MCB.00800-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16954383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16954383"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Indumathi Mariappan, Ritika Gurung, Subramonian Thanumalayan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of cyclin D3 as a new interaction partner of lamin A/C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2007.02.060"}], "href": "https://doi.org/10.1016/j.bbrc.2007.02.060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17321498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17321498"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Hongliang Zong, Yayun Chi, Yanlin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclin D3/CDK11p58 complex is involved in the repression of androgen receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01753-06"}], "href": "https://doi.org/10.1128/MCB.01753-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17698582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17698582"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Norman Balcazar, Aruna Sathyamurthy, Lynda Elghazi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "mTORC1 activation regulates beta-cell mass and proliferation by modulation of cyclin D2 synthesis and stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M807458200"}], "href": "https://doi.org/10.1074/jbc.M807458200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19144649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19144649"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Matthew H Cato, Suresh K Chintalapati, Irene W Yau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclin D3 is selectively required for proliferative expansion of germinal center B cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00650-10"}], "href": "https://doi.org/10.1128/MCB.00650-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20956554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20956554"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Masao Nakagawa, Shinobu Tsuzuki, Keiichiro Honma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Synergistic effect of Bcl2, Myc and Ccnd1 transforms mouse primary B cells into malignant cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3324/haematol.2011.041053"}], "href": "https://doi.org/10.3324/haematol.2011.041053"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21606168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21606168"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Vijay G Sankaran, Leif S Ludwig, Ewa Sicinska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.197020.112"}], "href": "https://doi.org/10.1101/gad.197020.112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22929040"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22929040"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Lori A Ehrlich, Katherine Yang-Iott, Amy DeMicco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Somatic inactivation of ATM in hematopoietic cells predisposes mice to cyclin D3 dependent T cell acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/15384101.2014.988020"}], "href": "https://doi.org/10.4161/15384101.2014.988020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25659036"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25659036"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Miguel Chaves-Ferreira, Gerald Krenn, Florence Vasseur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Direct (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13062-016-0122-9"}], "href": "https://doi.org/10.1186/s13062-016-0122-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27129404"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27129404"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Amy DeMicco, Tyler Reich, Rahul Arya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lymphocyte lineage-specific and developmental stage specific mechanisms suppress cyclin D3 expression in response to DNA double strand breaks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2016.1198861"}], "href": "https://doi.org/10.1080/15384101.2016.1198861"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27327568"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27327568"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "T Garcia Robles, R A García Fernández, P García-Palencia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hoxa-10 and Cyclin D3 Overexpression in the Decidual Reaction in a Superovulation Protocol in Young Adult C57BL/6J Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Vet Pathol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0300985816660748"}], "href": "https://doi.org/10.1177/0300985816660748"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27511308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27511308"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Silvia Giannattasio, Giacomo Giacovazzo, Agnese Bonato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lack of cyclin D3 induces skeletal muscle fiber-type shifting, increased endurance performance and hypermetabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-31090-5"}], "href": "https://doi.org/10.1038/s41598-018-31090-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30143714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30143714"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Juhee Pae, Jonatan Ersching, Tiago B R Castro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20201699"}], "href": "https://doi.org/10.1084/jem.20201699"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33332554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33332554"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Lina Petersone, Chun Jing Wang, Natalie M Edner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20221653"}], "href": "https://doi.org/10.1084/jem.20221653"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37466652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37466652"}]}]}]}