{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe studies collectively highlight that MIR6747, whose function appears intertwined with the activities of procolipase and its derived peptide enterostatin, plays an essential regulatory role in lipid digestion and energy homeostasis. In a mouse model lacking procolipase, the enzyme’s absence resulted in fat malabsorption on a high‐fat diet, impaired neonatal weight gain, and compensatory hyperphagia—all underscoring its critical function in fat digestion and in establishing a physiological body weight set point during early development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Disruption of normal gene regulation associated with MIR6747 was also observed in liver metabolic pathways where increased expression of procolipase, alongside the pancreatic-related protein 2, was linked to epigenetic modifications that enhance retinyl ester hydrolysis. Such regulation appears sensitive to changes in the S-adenosylmethionine/S-adenosylhomocysteine ratio, light exposure, and vitamin A signaling, indicating a broader role that extends into modulation of hepatic vitamin A metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "Furthermore, the release of the pentapeptide enterostatin from procolipase has been shown to contribute to developmental survival and lipid metabolism. Although enterostatin is not indispensable for controlling dietary fat intake or overall growth, its absence or replacement alters serum cholesterol profiles, and its administration in neonatal models of procolipase deficiency significantly improves survival. This suggests that MIR6747—via its precursor procolipase and cleavage product enterostatin—not only supports efficient fat digestion, but it may also influence cholesterol balance and developmental maturation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dymphna D'Agostino, Richard A Cordle, John Kullman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased postnatal survival and altered body weight regulation in procolipase-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M108328200"}], "href": "https://doi.org/10.1074/jbc.M108328200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11751900"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11751900"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wenqiang Pang, Ying Zhang, Shiming Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The mPlrp2 and mClps genes are involved in the hydrolysis of retinyl esters in the mouse liver."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M010082"}], "href": "https://doi.org/10.1194/jlr.M010082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21339507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21339507"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rita Miller, Dymphna D'Agostino, Charlotte Erlanson-Albertsson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enterostatin deficiency increases serum cholesterol but does not influence growth and food intake in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Endocrinol Metab (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpendo.91008.2008"}], "href": "https://doi.org/10.1152/ajpendo.91008.2008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19622781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19622781"}]}]}]}